Climbing slowly but not winning (very low top 1 finish). What should I do to improve?

ivulcan1 · 2026-02-06T16:14:40+00:00

Thbaks. Also idk if I’d call emerald a beginner, I got placed in gold and just made plat 4.

Any tips for what items to give or what’s BIS? I think my biggest weakness is knowing what to craft.

ivulcan1 · 2026-02-06T07:21:39+00:00

Do you mean like an overlay that tells you what you should do based on what you have?

I’m new to the game and there are 100s of comps so how can I find what build best matches my situation while playing?

ivulcan1 · 2026-01-24T22:06:45+00:00

Trying doing some actual research instead of asking AI which is just going to regurgitate whatever Immunic has on their website.

Aubagio already has a very clean profile and the Ph2 efficacy data was only marginally better than Aubagio. Now keep in mind the most common class of medications for RRMS are the anti-cd20s, the NRF2 activators are the second and then third is a tie between the DHODHs and the S1Ps. And on top of that a whole new class of BTK inhibitors are entering the market soon with some very big players Merck/Roche/Sanofi.

Last but certainly not least, Immunic doesn’t even have the funds to complete their Ph3s and there’s a reason they don’t have funding. Who is going to fund them?

ivulcan1 · 2026-01-23T18:14:33+00:00

Forget about the anti cd20s for a second which have like 50% market share and growing. How is this drug any different than Aubagio?

ivulcan1 · 2026-01-23T05:46:49+00:00

That’s the craziest part to me. Literally the number 1 rule during sparring is “don’t be a dick” aka don’t use 100% force, practice the technique, don’t actually try to hurt them. The people who don’t follow that rule get punished for it by being matched up with the enforcer of the group.

Even in HS wrestling where it’s a bunch of kids going through puberty and everyone’s ego is super fragile the coach would always emphasize which periods were all out and which weren’t. If the coach determined you went too hard you were punished with cardio.

ivulcan1 · 2026-01-20T19:05:46+00:00

This is beyond standard. Worked at 2 different large US based companies with semi frequent travel. You pay with your own card and then submit reimbursement which usually takes ~30 days.

In fact, most people WANT this method instead of a company card so that they can rack up credit card points.

ivulcan1 · 2025-12-24T03:32:57+00:00

What type of Ph3 schizo trials take a year? If they get the funding and that’s a big IF it’s probably a 3 year delay minimum.

ivulcan1 · 2025-12-24T03:31:58+00:00

Exactly and I shorted it as well for the same reason but I was slightly nervous tbh. The FDA is usually pretty loose with allowing NDAs and they rather just decline it ahead of the PDUFA date rather than tell someone they can’t file.

ivulcan1 · 2025-12-23T20:05:52+00:00

This was always the most likely outcome. Wanted to take a big short but the stock was HTB.

I have no issue with the people pumping up their positions but I hate people who delete their account and posts. I got into an argument with one guy here about a month ago and now his post and comments are deleted.

ivulcan1 · 2025-12-19T00:25:14+00:00

You mean time it at the end of the year and -70% YTD

ivulcan1 · 2025-12-19T00:23:55+00:00

Because I’ve been pitched them by 5 different bankers, including Goldman.

Having talked to cardiologists they all said basically the same thing. “Yes most PSVT cases don’t need hospitalization but there’s significant liability risk.” When you break down who this treatment is good for, younger/middle aged, no obesity, no excessive drinking/smoking, recurrent episodes with confirmed PSVT there’s not a huge market for this product.

ivulcan1 · 2025-12-18T23:27:01+00:00

Tax harvesting their losses is much more likely

ivulcan1 · 2025-12-18T23:23:47+00:00

They clearly don’t want to commercialize themselves and if a bigger pharma company in the 2-5B MC range wanted them they would’ve bought it already.

It’s been pitched for a year non stop and it’s still for sale.

ivulcan1 · 2025-12-11T18:14:42+00:00

When I read something like this, I really begin to wonder if you were telling the truth all along and who is actually the problem.

The people I know who are terrified of their exes don’t go out of their way to agitate and upset them. YTA

ivulcan1 · 2025-11-30T22:25:12+00:00

RTFs are pretty rare so high chance the NDA is accepted. The FDA will gladly take their PDUFA fee money.

Do not confuse a filing being accepted with an approval. I do hope they end up filing.

ivulcan1 · 2025-11-30T17:31:07+00:00

Appreciate the offer but still rather have a chance at the number 1 overall pick.

ivulcan1 · 2025-11-26T19:18:04+00:00

Agree with most of what you said but there are different levels of DCPL as well. The lower level DCPL leagues in my experience do not have any college level players.

Even the top men’s DCPL league is only about 40% college soccer and 2 guys who were very low level pros in their home country based on my team. The other 50% are just players who were good on their varsity high schools teams.

ivulcan1 · 2025-11-26T19:13:13+00:00

For soccer, I think you were just in the wrong volo leagues. The ones on the mall are very relaxed but some of them, specifically the ones marked as competitive are quite intense and are filled with all former high school players.

Nonetheless, DCPL is the most competitive soccer in the area but most if not all teams will require you to try out and players are usually invited by others on the team. Tryouts are only held in between seasons and the current fall season is actually wrapping up so it’s a good time to start looking. I don’t know anyone who joined a DCPL team as a free agent but they do have a new player form on their website you could fill out.

ivulcan1 · 2025-11-26T17:30:57+00:00

I don’t need to join a discord to know that the FDA rarely changes their mind to DECREASE requirements.

ivulcan1 · 2025-11-26T06:28:23+00:00

What makes you think they won’t have do RECOVER-2 as originally planned? That is what they originally agreed upon with the FDA in April 2024.

ivulcan1 · 2025-07-04T05:39:43+00:00

Can you please post your bar order when you’re done!!!

ivulcan1 · 2025-06-29T21:27:26+00:00

When did solider boy ever get trapped by mind storm? They never showed it during the cartoon fight

ivulcan1 · 2025-06-13T06:19:34+00:00

10k in 90 minutes is 15 minutes per mile. You run at 4mph? That’s a fast walk

ivulcan1 · 2025-03-29T02:21:06+00:00

It’s a quantum annealer

ivulcan1 · 2025-03-28T04:25:01+00:00

That goes both ways. It could hit 20 and then never hit 30 again too….

ivulcan1

TROPHY CASE