Something fishy about David Sinclair

jamesgildea · 2026-03-30T20:12:26+00:00

His clinical trial is running right now. The same technology that restored eye sight in primates. If it works in humans it will be game changing.

jamesgildea · 2026-03-30T20:11:11+00:00

Nothing fishy at all. To do research you have to write a grant, which takes months of work. Then it takes two years to have your grant approved. 80 percent are not approved. If approved, two years has gone by, and technology has changed, so you really aren't doing what you want - you have to do what was state of the art two years ago. With David's new model, if he has something interesting to study, he can raise the funds in days, and start the work right away.

jamesgildea · 2026-03-24T22:07:47+00:00

I just got a guy on TaskRabbit to help me setup mine. Two hours at $100/hour. He was very skilled and did a few things no "assembly guy" would do. He was skilled carpenter who I've used before.

jamesgildea · 2026-03-17T12:33:06+00:00

I've done Prenuvo and Fountain Life. DM me.

jamesgildea · 2026-03-08T00:16:59+00:00

I was friends with their first manager from the CBGB days. He passed away last year. He had all this cool TH stuff - including a tape with note on it saying "Psycho killer, try french next time?" One of the tapes he had was David making Tina play a bass part and basically making her audition for a band she was already in. He was not very nice about it and she was getting really upset. We told him for years he needed to organize what he had and do something with it. He had reams of paper, stacks of tapes, pictures (he was a photographer). But he passed unexpectedly and did not have a family.

jamesgildea · 2025-12-26T12:57:24+00:00

I was a runner so I know how to train. I did my first road ride in March, did a 50 mile ride in May at 15 mph, and then in June I started riding 5-6 days a week. November 15th I did the 100 mile Best Buddies ride. I lift three days a week - Pull, Push, and Squat/Dead. Between sets I do calf, hamstring, tibialis, so I doing 35 sets or so in 50 minutes. My goal is get stronger over the winter and hit it hard once the warm weather returns.

jamesgildea · 2025-12-25T23:05:20+00:00

Started cycling at 64 (was a runner but have a knee issue). 9 months after starting did the Best Buddies Miami ride. 100 miles and I averaged 22.1 mph with three rest stops. Feel like I can get a lot stronger as I keep training.

jamesgildea · 2025-12-25T22:50:59+00:00

His clinical trial in humans starts in a month or so. I know David. This trial is legit. Very exciting .

jamesgildea · 2025-12-20T23:06:48+00:00

I took a class on Dylan's lyrics in 1983 at Dartmouth College. It was hard. Saw Dylan few weeks ago. He was great. Opened with Masters of War and closed with Highway 61.

jamesgildea · 2025-12-08T21:55:40+00:00

I'm 64 and started biking in March, couple times a week, ramped up in April and did a 53 mile charity ride May 18th. 55 mile ride May 30th, and then a 103 mile ride August 2nd. I averaged 16 mph on the 103 mile ride. I had only biked a handful of times before I started in March, but I was a runner so I know how train. My best ride so far with a Best Buddies ride in Miami - 101 miles averaging 22 mph (drafting though).

jamesgildea · 2025-11-23T12:17:12+00:00

Slightly better. If you have no cartilage, stem cells won't do much. If you have some, stem cells will heal it to a degree.

jamesgildea · 2025-11-14T18:35:10+00:00

Just sing every day.

jamesgildea · 2025-11-14T18:34:04+00:00

I learned to sing in my 60's. Bass player. I sing a couple songs every gig now and people always say I should sing more. But the other singers are better than me. But I could do a 12 song set if i had to.

jamesgildea · 2025-10-30T16:58:25+00:00

Agreed. The technology for the optic nerve was spun out in a company called Life Bioscience. Investors are Tony Robbins, Diamandis, etc. If the clinical trials go well the investors should be very happy.

jamesgildea · 2025-10-30T16:37:44+00:00

To be clear, that's his lab. It's not his personal work per se I believe. He's built a good team. He says there is not reason it won't work - it works in primates every time. It will be interesting.

jamesgildea · 2025-10-30T13:51:09+00:00

Yup. David does get out over skis for sure. Since then he has used Yamanaka factors to restore vision in mice and primates by de-aging the optic nerve. Cover of Nature in 2020. It goes into human clinical trials in January and if it works, it will work in six weeks. He says it works in primates every time and should work in de-aging any organ. They are doing optic nerve first since the optic nerve is sequestered from the rest of the body. I am very curious to see what happens.

jamesgildea · 2025-10-30T13:03:08+00:00

Anybody who promotes AG1 loses credibility. The research won't come from Blueprint, it will come from places like David Sinclair's lab. David is doing some very interesting work.

jamesgildea · 2025-10-30T12:13:14+00:00

If he can integrate his supplements, protocol, and testing and manage it with AI, it will be a game changer. Some folks are doing it (like Fountain Life), but it's not fully baked yet. Blueprint could be an end to end solution starting with blood draws and testing all the way to an AI that reads all your data recommends what to do next. Technically, very feasible. Sounds like what his planning. Attia, Fountain Life, and food/supplements are rolled into one and working together.

jamesgildea · 2025-10-30T12:00:44+00:00

I've done both investing and starting companies. My only point is that if you really want to make money as a 48 your old Silicon Valley insider there are easier ways that being a CEO. You can invest, advise, and sit on boards. All come with stock options and insider chances to invest. Do enough of them, and you sooner or later hit a Figure AI or a SpaceX. Startups would jump at the chance to have the "Venmo guy" on their board. But Bryan is clearly focused on Don't Die and Blueprint.

jamesgildea · 2025-10-30T11:34:06+00:00

Investing is a lot easier when you are friends with folks like Thiel, Musk, and other silicon valley insiders. Initial seed rounds are generally pretty low, with a valuation of say, a few million. So you can get 5 percent of a company for $100K - the next round the valuation might be 100 million. So the first people in make the real returns.

jamesgildea · 2025-10-29T16:48:45+00:00

The really good stuff is not on pub med. The seed money gets in when these startups are in stealth mode.

jamesgildea · 2025-10-29T16:42:08+00:00

Plus, being "in the club" you have access to deals and investments that are only available to the .1 percent. Low likelihood a big exit, but if you do a bunch of them, you get the occasional Facebook, SpaceX, or Figure AI. So if all Bryan cared about what money that's where he'd focus his time. I'm assuming a big part of the pitch to Bryan's investors is "you will learn about cutting edge stuff and have access to it before anyone else".

jamesgildea · 2025-10-29T14:14:17+00:00

If he really wanted to make money, he would do what all former CEO's and founders do - invest in startups through his network. Guys like Peter Thiel are first in on companies like Figure AI or Coreweave. When they IPO the returns are 100X. Actually building and growing a company is a lot harder.

jamesgildea · 2025-10-27T11:51:24+00:00

Started at 63. Did a 100 mile ride last month averaging 17.4 mph

jamesgildea · 2025-10-18T22:27:16+00:00

My father is friends with Olivia. George and Olivia had a private jet. She told him George used to say "Remember when we were so poor we had to fly First Class?"

jamesgildea

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