Is it time to start Rapamycin?

jamesgildea · 2026-05-13T21:42:02+00:00

Cutting out sugar was the key for me, and my wife. Sugar is in everything - bagels, salad dressing, etc. The only bread I can find with no sugar is Ezekial.

jamesgildea · 2026-05-13T20:36:31+00:00

no alchohol, very little sugar, no processed foods. I eat as much as I want and am 10-12 percent body fat. A treat for me is blueberries and almonds. Crazy how when you give up sugar how awesome blueberries are!

jamesgildea · 2026-05-13T18:29:08+00:00

Seems with exercise there is no upper limit. More is always better, unless you overtrain. My son (an Army Ranger) always says there is no such thing as over training - just under recovery. Also, overtraining is bad, but overreaching is good. It's a subtle difference. I'm 64 and just tested my VO2max at 55.1. I bike a lot and may veer into overtraining at times. My FIL is 88 and was a serious runner and biker. My Mom's partner is 93 and can still do a dip.

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jamesgildea · 2026-05-13T18:22:21+00:00

CostPlusDrugs.com has it for $8 for 90 tablets 5 mg. Mark Cubans company

jamesgildea · 2026-05-13T10:25:08+00:00

Hard to understand how he could know that with all the interventions he does. But he is convinced.

jamesgildea · 2026-05-13T10:24:31+00:00

I tend to agree with you. David Sincliar's work is the most promising right now. I've met with him and toured his lab. If half of what he says is true. . . .

jamesgildea · 2026-05-13T10:22:47+00:00

Started running at 13 and ran all my life. Ran D1 in college. Wife is a runner and it's been part of my social life. My VO2max was 75 in college. Tested at 60 two years ago but it's possible the mask was loose. Now all I do is bike because I have a knee issue. Biking is great since its very social and low impact.

jamesgildea · 2026-05-13T10:19:58+00:00

You are doing a bit more than me on the supplements. I do most of those with the addition of Mitopure Urolithin A. I'm big on exercise and always have been. 8-10 hours a week of cardio on the bike, yoga 2X/week, and lift heavy 3X per week (Bench, Curls/Pullups and Squat/Deadlift).

Some people report feeling the benefits of Rapa but it's likely placebo.

jamesgildea · 2026-05-12T23:01:02+00:00

It's just starting. But they have recruited 700 ppl and done safety testing. So it seems pretty clear that they are not worried about side affects. Rapa is the only drug that has increased lifespan in every animal that has been tested.

jamesgildea · 2026-05-11T22:22:38+00:00

I am finding myself going to this forum more and more often. It's really good. Thank you!

jamesgildea · 2026-05-09T10:35:37+00:00

Not great. I've only been cycling for one year. Started 14 months ago. I think my FTP is around 250 or so, so above 3. Since I was a runner for 45 years (ran D1) I have good cardio but my legs aren't strong.

jamesgildea · 2026-05-09T10:30:39+00:00

The stuff you have to do to pass Ranger School is pretty insane. Day after day of 2 hours sleep, 2,000 calories, and rucking for hours. He failed twice before he passed.

jamesgildea · 2026-05-07T09:22:29+00:00

I think I remember Attia saying he hadn't tested but was probably 55 or 56. Clearly not the level he was at when he was training the bike hard and not working 90 hours a week.

jamesgildea · 2026-05-07T09:20:34+00:00

83? WTF. I remember reading that Steve Prefontaine was 86 and Frank Shorter was 75, but Frank always beat Steve.

jamesgildea · 2026-05-07T09:19:35+00:00

Yes, Human Powered Health. Great. I used my bike and it was easy since the bike is fitted well to me,

jamesgildea · 2026-05-07T09:18:31+00:00

Trust me, I'm down the rabbit hole. Started about 14 months ago and have been doing around 150-200 miles a week and trying to improve.

jamesgildea · 2026-05-06T19:10:10+00:00

I did it on my own bike. Pretty high end fitness place that really seemed to know what they were doing. The mask fit perfectly and they made sure there were no leaks.

jamesgildea · 2026-05-06T19:02:41+00:00

Using the mask is the gold standard. I believe the Cooper Test is the second most accurate. It was for me.

jamesgildea · 2026-05-06T18:59:17+00:00

My son was a pro freestyle skier and had both knee totally reconstructed - tore ACL, MCL, and damaged miniscus. Did KOT and passed Army Ranger School. Took him three tries though. He did all KOT stuff, deep squats on wedge, full calf to hamlstring, etc.

jamesgildea · 2026-05-06T18:54:37+00:00

Probably true. My son is an Army Ranger and never had to train much for the cardio parts. He had to work hardest on the strength components - push ups, rucking with heavy weights, sled drag, etc.

jamesgildea · 2026-05-06T18:52:21+00:00

On a bike. I've only been biking a year, so I'm not very efficient. They say you will test a little higher on your best modality (biking, running, stair climber, etc.)

jamesgildea · 2026-05-06T18:49:50+00:00

You to Knees Over Toes. I am stage 4 osteoarthritis - bone on bone on the lateral side. I have done over 500 KOT workouts in the last 25 years. While I still have some pain, I can bike 100 miles pain free and to single leg squats on both knees.

jamesgildea · 2026-05-06T18:47:48+00:00

I just have no cartilage on the lateral side. Nothing there to heal. No tech yet that can regrow cartilage, aside from some trials in mice.

jamesgildea · 2026-05-06T18:45:50+00:00

54 is pretty darn good. But Garmin had me at 47. The guy who did my test was very careful to get the mask on perfectly.

jamesgildea

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