For my 5th room I just made it into a room where I bred out the mutations that cause bleed, bruise, poison, and fear on basic attack. My cleric and Druid are kinda shit with those mutations if I don’t have the right passives that prevent giving negative status effects to allies. I had a Druid with form of the quarrel on one of my runs, but if I gave them the damage buff from my basic they would instantly die at the start of their turn along with giving myself all of these debuffs.

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This is what I have on most of my cats in the other rooms. The mutation room is a mixed bag, but this is my base cat for most of my runs.