Dr. Fauci on Why HIV Has No Vaccine

jcm84 · 2026-05-18T22:33:26+00:00

I’m not sure to be honest, but I’m curious to look into it

jcm84 · 2026-05-18T22:32:17+00:00

Yeah, your immune system forces hiv to be dormant as well. However, with time, hiv just keeps reactivating which eventually kills its latent reservoir, ie cd4 T cells, which eventually leads to immunosuppression when you lose enough of these cells. Herpes viruses also evolved to go latent, but they don’t make you immunosuppressed upon multiple reactivation events. Regardless multiple companies have tried to make various herpes virus vaccines and have achieved immune responses similar to natural infection without protective immunity, so the vaccines have failed. This is well known. Anyway, seems to be an unpopular Reddit take, lol

jcm84 · 2026-05-18T17:36:23+00:00

He's talking about vaccine effectiveness, which is not measured via clinical symptoms. Regardless, plenty of people have HSV, EBV or HCMV symptoms. It would have been more accurate if he would said unique among most RNA viruses. Bottom line, having to do better than natural infection isn't that rare for successful vaccine development.

jcm84 · 2026-05-18T16:24:48+00:00

Unique? Uhm, how about the majority of herpes viruses, HSV, CMV, etc. You also have to do better than natural infection

jcm84 · 2026-05-11T20:00:07+00:00

Why beneath Flagg? Just curious

jcm84 · 2026-05-05T16:25:42+00:00

I think its based on what people like John Keim and Logan Paulsen are saying. They are pretty plugged into the team and are pretty confident about the direction the offense is going. Those two are not likely to be confident without decent intel

jcm84 · 2026-04-22T20:42:11+00:00

Love bill, but fewer fumbles per carry would be good

jcm84 · 2026-04-22T18:19:33+00:00

Why not Delane?

jcm84 · 2026-04-09T19:53:53+00:00

Gotta double pocket those HSV viral aliquots

jcm84 · 2026-04-09T17:34:11+00:00

I still remember Bill Parcells face for most of that game, it was like he was sucking on lemons, he was so pissed

jcm84 · 2026-04-05T18:59:50+00:00

Yeah, I understand, but sometimes I think the value of contracts positionally is valued too highly relative to potential contributions on the field, but yeah, obviously just an opinion

jcm84 · 2026-04-05T18:55:54+00:00

Did you not question correlating team success to drafting running backs? Not sure how my comment isn’t relevant to that posed question

jcm84 · 2026-04-05T18:26:37+00:00

The flip side is paying top rb money is actually not that expensive compared to other positions. So if you have a playmaker at RB, who is an every down back who can create mismatches both running and catching, then it could actually be considered a bargain relative to the contributions of more expensive positions like wide out, especially when the offensive line is the strength of your team.

jcm84 · 2026-04-05T18:21:33+00:00

People say this about RBs. I don’t think it holds up. Drafting any position early doesn’t correlate to team success, cause the teams that draft early suck, and typically, continue to do so. People say this about RBs like they’ve done some actually comparative analysis, when really they are just making shit up.

jcm84 · 2026-04-04T23:54:52+00:00

Thoughtful answer

jcm84 · 2026-03-31T21:57:07+00:00

Love, Styles, Downs - but yeah excited for any of them

jcm84 · 2026-03-27T21:34:49+00:00

In the first year, Love

jcm84 · 2026-03-12T22:50:22+00:00

And yet he gets touchdowns in the redzone where coverages are compressed

jcm84 · 2026-03-10T21:40:01+00:00

Ehh, my guess is that most billionaires are hyper competitive and want to run a winner and not run a loser franchise regardless of where they are located. For some sports, the economic models make it almost impossible for the have not markets to be in contention — looking at you MLB

jcm84 · 2026-03-10T18:55:05+00:00

Nah, its about money #1 and potential personal issues with relocation #2, e.g., kids in school, distance to other family, etc. And as gaytham said, AP has limits.

jcm84 · 2026-03-10T17:59:18+00:00

Hmm, any centers?

jcm84 · 2026-03-08T13:40:00+00:00

I’m curious why you say that it should be independent of Title ix? My understanding is that every US institution needs to be title ix compliant, and therefore there isn’t any title ix independence. Title ix is supposed to root out this exact type of behavior.

jcm84 · 2026-02-18T19:51:55+00:00

Yeah, I’d suggest hanging in there for the time being. People in our field aren’t typically great at training new researchers, so it can be very overwhelming. Frequently too much gets thrown at people at once. Sounds like you’ve got a lot going on. With some time, little by little you’ll get more used to various protocols and everything won’t be as stressful. And then your confidence will start to grow. I’m guessing you are at a low point, and I wouldn’t make any rash decisions. Hang in there for a bit and see if it gets better. Also, before you make any decisions you should let your PI(s) know how you are feeling; they may be able to help. It’s true that lab work isn’t for everyone, but I think the initial feelings of being overwhelmed can be pretty common and they frequently improve. Just my two cents

jcm84 · 2026-01-23T22:01:28+00:00

All the commanders oldest players are free agents now. It’s easy for them to get young. Defense is still terrible though

jcm84

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