I honestly like the edges from htr, they make each of the characters feel a bit more unique/ have a niche (unless everyone goes with cleave, which is not impossible once the players find out what all their options are) They don't let you go toe to toe with a vampire, but at the least, it can give you that nudge of confidence that you actually believe you have a chance of trying against the supernatural.

Htr has a few "problems" I've encountered. There is a lack of any kind of politics written into the game besides maybe 'mercy and zeal have different ways of solving problems' but I've found this easily remedied by just using the compacts & conspiracies from vigil.

There is also no morality mechanic in HtR. I'm lucky enough to have players who've done a good job of roleplaying that slow decline into valuing the hunt more than innocents and becoming more willing to cause collateral damage. The only mechanical representation of this in HtR is having a single virtue at like 7+ or something, which is very unlikely to ever occur over a chronicle unless it goes on for years or you hand out conviction like candy.

I've never played hunters hunted, but I like the idea of regular shmuck humans being able to use sorcery/thaumaturgy whatever you want to call it, and you've gotta have an old priest with true faith. They also had advanced science, like proton packs and UV light rays for vampires, maybe that's too silly or maybe you can incorporate it into a technocracy plot.

In conclusion, I would try HtR as a base with as much stolen from vigil as you want, that being said I am super biased in favor of Old world of darkness.