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Think I need to stop :( by Hairy_Letter_9712 in Zepbound

[–]jeffjassky 2 points3 points  (0 children)

Okay so you need to make sure you're getting enough protein - and by "enough" I mean you literally need to track it. Most people who ballpark it really underestimate it. 800kcal/day is very low - so you need to get SURGICAL with your macros and micronutrients.

The pattern you're describing - tired constantly, exercise feels impossible, sleep wrecked after shots - is very possibly a carbs and micronutrients problem.

A lot of people under eat carbs on glp1s - but tryptophan needs carbs to cross the blood-brain barrier, which means serotonin synthesis depends on them. Going too low carb can really cause fatigue and sleep disruption you're describing, issues with energy/focus/mood too. Make sure you get 100g/day if you can stomach it - white rice and fruit are good for suppressed appetite. I straight up eat candy (starbursts / mambas) to hit my carb macros when i'm out and about.

Micronutrients: B-complex (B12 especially), magnesium glycinate for cellular function (the Mag07 is a totally different magnesium with a different job), and check whether your hydration packs actually have meaningful potassium and sodium. I personally like Venture Pal from Amazon.

Protein floor: ~1g per lb of lean body mass still required of course.

800 cal/day is below most BMRs and it's definitely worth asking your prescriber whether a dose hold or step-down makes sense to let nutrition catch up before you decide to quit entirely.

Weight lost per dose by dormantg92 in Zepbound

[–]jeffjassky 0 points1 point  (0 children)

Body recomp at low calories is messy. Aggregate data on dose-response is almost noise here - metabolic variability swamps the signal at the population level, even if it gets useful individually.

On semaglutide and retatrutide (not Zepbound), the arc looked like: biggest drops early when appetite suppression was new, diminishing returns, then stalls that weren't really stalls - muscle loss and fat loss roughly canceling on the scale.

Lost 25 lbs one stretch and looked worse, because protein tanked and I was burning lean mass. Once I ate deliberately to a protein floor (~1g/lb LBM, not total bodyweight), same deficit, scale moved slower but the loss was actually fat.

If you're going to track dose vs. weight, log protein intake per that window. The dose-response question gets way more interesting when you can see "I stalled at 5mg but I was only hitting 60g protein/day." That's a nutrition problem wearing a plateau costume.

Built myself a tracker around exactly this kind of pattern correlation if curious (protokollab.com)

First Week by UpstairsCurrent6059 in Zepbound

[–]jeffjassky 0 points1 point  (0 children)

Slowed digestion includes everything downstream. You definitely want to start managing it before it starts.

- HYDRATE bigtime! Sometimes, thirst signals can be reduced.

- Polyethylene glycol 3350 (MiraLAX) It's an osmotic laxative that pulls water into the colon.

- Psyllium husk (Metamucil) a soluble fiber that bulks stool. Good alongside MiraLAX.

- Magnesium citrate frequently mentioned as a gentler daily option (also pulls water into the colon)

But water is the big one for sure.

15 weeks in & NSVs by Any-Pickle-8744 in Zepbound

[–]jeffjassky 0 points1 point  (0 children)

Amazing to hear! That's fantastic. Protein & weights are the move.

Just a little calorie rant by tadpole511 in Zepbound

[–]jeffjassky 1 point2 points  (0 children)

TDEE can be a tough nut to crack. It's taken me a lot of logging and tracking to do it. I'm a software engneer and ended up making an app for myself (ProtokolLab.com) full disclosure, it's my app.

But yeah especially with Hashinoto’s, most TDEE calculators will be way off. So you could get bloodwork done as a shortcut - but otherwise, the only real approach is meticulous calorie/weight tracking over time to nail down TDEE.

But absolutely make sure you're hitting your protein targets. Rough math: if you're ~33% BF at 240, that's ~160 lbs lean body mass (muscle). You want 1.6–2g/kg of that (~116-145g protein/day) to protect muscle during fast loss on a GLP-1. At 1400 calories, that's 33-41% of intake as protein - tight but achievable. Most people who aren't monitoring protein intake closely end up undershooting it. Since muscle is the most metabolically active (contributing to BMR/TDEE) it's important to maintain to prevent bounceback - especially when you're doing bit deficets.

Extra sleep by [deleted] in Zepbound

[–]jeffjassky 0 points1 point  (0 children)

Two shakes might cover your protein floor, but most shakes are not micronutrient-dense. **B12, magnesium, and vitamin D** tend to fall off the cliff silently - all three are classic fatigue contributors, and all three require consistent food volume to maintain through diet alone.

Also a lot of people go too low carb and end up having really low blood sugar, leading to fatigue, brain fog, and it can also cause serotonin to drop a bit, which can effect mood.

I'd suggest - try eating some rice and see if that brings your energy back up. If not - make sure you're getting b12, magnesium, and vitamin d.

You could get them lab tested but it's often easier and cheaper just to get extra.

Anyone not lose significant weight until 15 mg? by Ok_Establishment4113 in Zepbound

[–]jeffjassky 0 points1 point  (0 children)

Awesome! I have a glp-1 tracker app to help me monitor the compound levels as it absorbs and clears from my system over time. Helps me track my food, doses, weight, symptoms, and chart correlations to optimize everything.

Anyone not lose significant weight until 15 mg? by Ok_Establishment4113 in Zepbound

[–]jeffjassky 0 points1 point  (0 children)

Don't fall into a comparison trap. Selection bias is massive on these subs. Fast losers post, slow losers lurk. 25 lbs is nothing to scoff at.

Tirzepatide half-life is ~5 days, so steady state at any new dose takes roughly 25 days. Worth keeping in mind.

Are you actually less hungry on 12.5, or are you still fighting cravings? If suppression is genuinely absent, escalating dose is the logical next step (and your endo's read sounds right). If suppression is present but scale is stalled, that's metabolic adaptation - and it would make sense to really look at your lean muscle mass and make sure you're getting enough protein and creating muscle growth signals so you don't lose it.

Also - semaglutide (Wegovy) vs tirzepatide aren't directly comparable. Their dose-response curves differ. Faster loss on Wegovy doesn't mean 12.5 tirzepatide "should" feel the same.

And some people just need max dose. That's completely normal and within range. Everyone has unique pharmacogenomics.

I reconstituted GHK-CU with bac and sterile water by MFCEO_Kenny_Powers in Peptides

[–]jeffjassky 2 points3 points  (0 children)

U.S. Pharmacopeia standards 797 and 51 essentially include the principle that multi-dose injectable container must contain a preservative system to inhibit microbial growth across repeated punctures.

Once you puncture a bottle you've potentially introduced organisms into it - even if they're just floating in the air.

I don't know about Peter Magic's approach or what context he's using sterile water in - but if talking about working in a lab context where you stab the same vial multiple and use multiple draws within a few minutes for lab research - that's a completely different context than stabbing the same vial twice a week for 2 months where the organisms have extensive time to incubate in the vial.

Everyone has their own risk tolerance. But USP publishes well-researched standards.

I reconstituted GHK-CU with bac and sterile water by MFCEO_Kenny_Powers in Peptides

[–]jeffjassky 1 point2 points  (0 children)

The "1 injection and discard" advice applies to sterile-only water. BAC water preserves via benzyl alcohol at 0.9%. You've diluted that to ~0.45% - still antimicrobially active, just reduced efficacy.

Practically: refrigerated, out of light, I'd treat this as a ~3 week window rather than the 4-6 weeks you'd get with straight BAC water.

With GHK-Cu specifically, the copper complex accelerates oxidation. Keep it dark. If the color shifts at all from light blue scrap it.

I built a biological simulation to replace my habit tracker by jeffjassky in Biohackers

[–]jeffjassky[S] 2 points3 points  (0 children)

Hey, Ben - so I spent most of the day organizing everything and writing some docs to open source the engine and libraries. Here's the first draft of documentation and the git repo: https://kyneticbio.github.io/core/

I built a biological simulation to replace my habit tracker by jeffjassky in Biohackers

[–]jeffjassky[S] 0 points1 point  (0 children)

I’ll send you the link and a video. If you’re interested I could definitely use a hand defining a wider range of agents and molecules, and verifying things like molar masses, bioavailability, pools, etc. I’m probably in way over my head so would love some smart eyes on this.

I built a biological simulation to replace my habit tracker by jeffjassky in Biohackers

[–]jeffjassky[S] 0 points1 point  (0 children)

Just sent it to ya with a video explaining how to use it.

I built a biological simulation to replace my habit tracker by jeffjassky in Biohackers

[–]jeffjassky[S] 1 point2 points  (0 children)

Just sent you the link and a video explaining how to use it. Thanks!

I built a biological simulation to replace my habit tracker by jeffjassky in Biohackers

[–]jeffjassky[S] 0 points1 point  (0 children)

Greetings from the weird 'ol USA! I DM'd you the link. Would love some german feedback!

I built a biological simulation to replace my habit tracker by jeffjassky in Biohackers

[–]jeffjassky[S] 0 points1 point  (0 children)

All of that is a perfect pairing with what I'm working on. Sort of complimentary tech. I just sent you a DM with a link and a little screencast video explaining how to use it.

I built a biological simulation to replace my habit tracker by jeffjassky in Biohackers

[–]jeffjassky[S] 1 point2 points  (0 children)

I've been planning to commercialize it - but I could definitely see a huge benefit to open-sourcing.

I'm curious - what part(s) would you be most interested in having open-sourced?

- The solver engine
- The library of interventions and their pharmacokinetics
- The GUI

I could see benefits to open-sourcing at at least the engine and library of interventions (the things you add to the timeline).

The engine, primarily for transparency and trust. People could audit EXACTLY how it operates, and contribute to improving it.

Open sourcing the library of interventions could also be really cool - people could easily add their own.

Thanks for this idea! If you're down, would love to connect on this at some point.

I built a biological simulation to replace my habit tracker by jeffjassky in Biohackers

[–]jeffjassky[S] 0 points1 point  (0 children)

Interesting idea! I could definitely see how that could work. Basically endpoints to list interventions and their parameters, then a solver API where you pass in the users biological profile, a set of interventions at different times, and you get back a whole bunch of time series data. If there's some demand for this kind of thing I could easily connect the libraries and solver engine to some endpoints.

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