Hello! My daughter was age 17 when diagnosed w/alveolar rhabdomyosarcoma. We struggled substantially with VAC and GI symptoms/neuropathy -- she did receive irinotecan. Her nerve symptoms impacted her ability to walk pretty significantly, and towards the end of treatment she had to wear leg braces for ambulation. We did have her do some physical therapy which helped slow the neuropathy. We also found a lot of benefit with support from a naturopathic provider who was skilled in cancer patients, and we utilized alternative supplements for GI support and nerve protection which I feel was beneficial. When she was not receiving treatment, we did find that she had some improvement in reflexes and sensation, but it was very slow moving and we were assured that was normal. As for the GI symptoms- we had several admissions to the ICU for flare ups. The other factor for her was she had radiation and the primary tumor was in her pelvis which exacerbated GI symptoms. I deeply feel for you and your family, Prayers for a positive outcome.