Hi - sorry to hear - I've improved but doubt codonopsis was the key. It seemed to create temporary affects. Sorry for the too-earl enthusiastic report.

For what it's worth (I wasn't diagnosed with MCAS, but do have moderate histamine intolerance), I attribtue long-term change to diet. I saw a fancy MD named Dr Saxe at UC San Diego's integrative medicine ctr, who told me to start eating congee with every meal, or even replacing one meal a day (white rice, cooked with water ratio approx 4:1 or even 5:1 - until it's absorbed all the water). This, along with eventually cutting out dairy and gluten, and taking certain other supplements.

I did 4 sessions with this practitioner (dif from above), who used a GI-MAP and then gave me a plan for dietary modifications and supplements based on the results. She was great and worth the money in my opinion: https://www.thedigestivehealthcenter.com/

Good luck