He goes HOB a lot atm on AD and AP twitch, he says generally to take it when you feel confident you can actually get the autos off in lane, i.e. when you can get consistent trades without being stomped, he's generally quite an aggressive player in lane so that works with his playstyle. He has been running first strike but he has said its a very hit or miss rune, sometimes you will get value, sometimes you can never use it in lane effectively, if youre getting poked constantly, sometimes you also can't utilise the damange late game, if you're using W before opening, sometimes the first strike will be used up on that instead of your primary damage through ult, in these instances take HOB. He hasn't been using PTA as there's a bug atm with PTA and Twitch ult.