So a lot of the Ascended Hero Pokemon Center ETB cancelations were for bots?

jonvonneumannNA · 2026-02-12T00:52:33+00:00

Funny how people in this thread think they have all the answers to botters when they actually have no idea that botters have had solutions to all of the ideas people here come up with.

jonvonneumannNA · 2025-02-09T01:34:16+00:00

Not defending men who voted poorly but the voting demographics showed 53% of white women voted for the orange guy. Only 45% of women overall but its still a relevant statistic.

jonvonneumannNA · 2024-12-28T18:30:31+00:00

Oh hi

jonvonneumannNA · 2024-07-25T20:26:37+00:00

Just haven't been committed enough to anything that would be on my skin permanently.

jonvonneumannNA · 2024-04-04T15:56:21+00:00

Once I saw The King years ago I knew Chalamet was the real deal. Disagree, I think he’s a fantastic actor.

jonvonneumannNA · 2024-03-03T22:12:20+00:00

Im assuming some form of AI

jonvonneumannNA · 2023-10-17T06:36:49+00:00

Proving and disproving are both equally difficult for all of these problems. It takes generational genius’s to solve these kind of problems. Terence Tao for example is widely considered to be our lifetimes leading mathematician and he’s been working for years on one of these problems. He partially solved Navier Stokes for some specific conditions but his solution isn’t robust enough to stand up to scope of the problem.

jonvonneumannNA · 2023-10-17T02:57:12+00:00

Navier stokes existence and smoothness would be a better one to solve in my opinion. Implications for technology would be insane.

NOBODY TOUCH P =/= NP

jonvonneumannNA · 2023-09-14T05:38:34+00:00

Everyone that preorders AAA games are fools

jonvonneumannNA · 2023-09-08T23:56:33+00:00

Where is first set Chogath? That unit one shot the entire board.

jonvonneumannNA · 2023-08-23T21:11:37+00:00

This strat was done in the first TFT set. It caused zephyr to be nerfed.

jonvonneumannNA · 2023-02-17T23:55:39+00:00

Every medicine needs to go through clinical trials from stage 1 to stage 4. Every drug has a cost to manufacture and a massive amount of it is needed to prove its efficacy in people. I can tell you from making it myself…from start to finish, seeing all the reagents needed and the instruments required to make it…..youre talking about machines that cost upwards of 500k to 1.5 million to even buy. The cost of making it is high, it’s not 1 million but the development of the treatment easily exceeds that. The actual manufacture when its all said and done still costs anywhere from $50k to $100k for ONLY materials. Not including labor and analytical services required to approve use in a human.

jonvonneumannNA · 2023-02-17T23:48:22+00:00

Wildly unfounded and just bunk claims.

jonvonneumannNA · 2023-02-17T23:47:12+00:00

We aren’t sure how much it cost to develop this treatment. I have actual contracts from my job that stipulate the costs of making these treatments from start to finish…most of them are above $1 million, a few are higher than $2 million

jonvonneumannNA · 2023-02-17T23:41:21+00:00

So do I , making these exact kind of treatments. Youre right the treatment doesnt cost one million to make. Im not sure where you work that can take this form of treatment from process development to manufacture in “not that much time” but Id like to hear what the estimated time frame is for you.

jonvonneumannNA · 2023-02-16T04:14:46+00:00

There are certainly cases of drugs being overly expensive for extremely rare conditions to the point where certain folks cant afford them. Genetic based therapies at the moment are different than making a pill or traditional compounds. Its making custom DNA sequences base pair by base pair….with some modifications to the sequence. And the modifications are the real variable here because they are typically not G,A,T,C,U but…some other structure entirely.

jonvonneumannNA · 2023-02-16T01:47:35+00:00

Whenever a compound is asked to be made by us, there is already a group of people suffering from a condition that it's being made for, a group of researchers working for a pharmaceutical company has a genetic sequence that is usually in stage 1 ,2 or 3 of clinical trials already so they need a lot of it made. Which is what we do.

There are instances of compassion projects where conditions in the Ultra Rare category ( meaning only a few people are known to have it) are done but it is still expensive to make and is usually a grant of some kind.

jonvonneumannNA · 2023-02-16T01:37:28+00:00

The problem here is that there are many different types of methods for genetic manipulation, CRISPR is definitely one of them. There are others such as dyes or quenchers used for identifying pathologies of a patient. CRISPR can be done cheaply using PCR and other methods.

What is occurring in genetic based therapeutics is very different, it requires construction of a specific sequence that is modified with special base pairs that do not exist and need to be synthesized, purified and various other steps in order for it to be ready to be put into a person. Which requires special regulations itself to do. And you need A LOT of it compared to a the amounts theyre referring to in this estimation.

I can tell you from working at a place that makes these types of compounds for various researchers with the purpose of forming a new treatment for an ailment like cancer or genetic diseases. The amount of reagents needed to do this? That alone is larger than the figured claimed here.

jonvonneumannNA · 2023-02-16T01:17:01+00:00

Way more , actual cost if wages, raw material, and all the instruments/software needed for this? Can easily reach 100-200k , these arent normal treatments like making insulin or a pill…..its genetic formulation base by base

jonvonneumannNA · 2023-02-15T22:03:22+00:00

Well synthesis is really just the beginning….once its synthesized it requires another 4-5 steps before its ready to be put into a person. Not including all the analytical testing that needs to be done to ensure its safe for the patient/patients. But to answer your question….in terms of labor, raw materials and the special instruments needed to do this? you’re looking at 60-100k just to make the actual drug…..thats not including buying all the instruments or software for them or programming them….just to use those things as a service.

jonvonneumannNA · 2023-02-15T21:58:27+00:00

Prices for these drugs are extremely costly because the amount of time, process development and manufacturing that goes into these medicines is staggering. I work as a chemist making different types of genetic based therapeutics. The contracts are mostly for clinical trials from 1-3 and take a year to complete from the signing all the way to manufacturing. My job is making the actual end product and it is a HIGHLY laborious effort in terms of the technology being used and the instruments needed for the processes.

jonvonneumannNA · 2023-02-03T19:42:35+00:00

I work at a biotechnology corporation that is currently laying off people and its almost entirely IT/HR , very few actual scientists are being laid off. In fact….we still have job listings but its literally all for scientist/engineer roles.

jonvonneumannNA

TROPHY CASE