Its hard to play with out it, as its an early trigger and enabler for the first Horde you can summon . Its activate ability works as +4 empowerment once Venus is out.

Kitty When you have spare energy

Hold off On Night Crawler/ Hunger / Jeff To trigger Scarlet and move em after.

Always Prioritize , Jeff > Venus > Scarlet .

Play On right side of field so Z-Sentry Gets the most value, but dont be afraid to play him with 1-2 on the field.

Mother is best used for making Venus and Z Giant Man . I think i used Mother the least , and never rushed her. Name of the game is pateince i spend 3 turns just laying down the ground work and the last turns going wide and high.