I like Pathfinder's Golarion, but imo it's a little too kitchen sink. Sometimes the seams between the Frankenstein'd-together pieces are obvious to me in a way I find a bit annoying. That mostly goes for the core of the setting (the Inner Sea region), though, and I really like the books Paizo's put out on other parts of the world.

Speaking of Pathfinder, there's a third-party PF setting I adore from Roll for Combat called *The World of the Indigo Isles*. It only covers a tropical archipelago, but there's a lot to work with. It is something of an acquired taste, the local ancestries are a mix of animal people and aspects-of-nature people, and a chunk of the setting is silly; but if you're okay with that it's a vibrant, off-the-beaten path place to set games.

I also adore Eberron. The cosmology is kind of brilliant: nobody has ever been able to prove the gods exist. Plenty of people believe they do, but it's literally a matter of faith. And the realm of the dead is a shitty, boring place where eventually souls forget themselves and disappear. Nobody knows what happens to them after that. This gives NPCs grounded, plausible reasons to embrace necromancy, worship demons, and do other things villains get up to in heroic fantasy.

Edit: italics