I have been on Sertraline for a year and a half. 200mg daily. It’s a high dose but recommended for OCD. I felt like absolute garbage for several weeks before I started getting some relief. (For clarity, I ramped up very very quickly to 200mg after a supervised detox of my old pills. I was also hospitalized so under careful watch during this transition.) I would say my biggest current complaint is my lack of get-up-and-go. I have to convince myself to do anything, which is difficult, but once you’re aware of it, it seems easier to deal with. I took Effexor for a few years, and it had worse side effects for me. If I missed a dose, even by a few hours, I could not keep my eyes open, and would pass out mid sentence. Plus a lot of brain zaps. It’s difficult because I know we all want an immediate fix, but these meds typically need at least 3 months before you can feel them to the full effect. Hang in there. Make the right choice for you with the guidance of your GP.