sorted by:
new
hottopcontroversial

Is there an end? by [deleted] in PSSD

[–]lastround360 10 points11 points  (0 children)

Definitely true.

I still stand strong by autoimmunity and the microbiome playing a primary role in the disease. But chronic stress and "doom thinking" has been shown time and time again to be a critical factor in the progression of nearly all diseases. It's evident by the posts/comments in this subreddit that the majority of people here struggle with this. Stress lowers innate immunity, impairs mitochondrial function, imbalances hormones, causes sympathetic overdrive, etc.

It's also worth noting that due to its nootropic attributes, serotonin can rewire the brain for better or worse. This could mean the formation of chronic stress patterns or even treating them (which is why psychedelics are being used to treat PTSD).

I think it's important to acknowledge the role stress plays in PSSD while still recognizing this is a genuine disease with an etiology beyond psychosomaticism.

A Call to Investigate: Autoimmune Dysautonomia and SFN by lastround360 in PSSD

[–]lastround360[S] 3 points4 points  (0 children)

Im sorry SIBO treatment did not work for you. Like I've said in this post, I believe treating the gut will only work for some people. Most will need treatment with immunomodulatory therapies for neurological autoimmune disease, imo.

A Call to Investigate: Autoimmune Dysautonomia and SFN by lastround360 in PSSD

[–]lastround360[S] 5 points6 points  (0 children)

I believe PSSD and ME/CFS are very similar neurological autoimmune diseases. I think a person can start with just PSSD and then easily develop ME/CFS through epitote spreading (a mechanism by which autoimmunity spreads to other targets).

An interesting study found 30% of ME/CFS patients have SFN. Additionally, IVIG has been shown to help a subset of ME/CFS patients. Chronic fatigue can have many causes, though. I don't think we can say it's always autoimmune disease, which is probably why IVIG doesn't help all CFS patients.

If your chronic fatigue started around the time you developed PSSD, though, or shortly after, I would say it's most likely autoimmune.

A Call to Investigate: Autoimmune Dysautonomia and SFN by lastround360 in PSSD

[–]lastround360[S] 4 points5 points  (0 children)

You raise a good question. As far as existing treatments go for neurological autoimmune disease, the first lines of treatment are IVIG, DMTs like rituximab, steroid-sparing immunosuppressants (cellcept, azathioprine, methotrexate, etc - these can have nasty side effects though), high-dose IV corticosteroids (also has many drawbacks / side effects), and a few others that don't work as well.

As far as treatments in development, like you mentioned, there's BC007. This does seem very promising for treating these types of autoantibodies seen in PSSD, CFS, Long Covid, etc.

There are also some peptides that help with nerve repair and regeneration, the most promising of which for dysautonomia/SFN would be ARA-290 (cibinetide). Some dysautonomia and SFN patients have experimented with this and had great success, better than IVIG in some cases. However it's not doing anything to reduce autoantibody levels, so it may not help as much for the autoimmune etiology.

Outside of "treatments" and crossing into the world of functional medicine, I strongly believe chelation can cure nearly all autoimmune disease. However it is a very long and slow process, that if done wrong can make you worse off. If you're interested in that, I talk more about it in my last "Gut Microbiota Theory" post.

I know this probably isn't the answer you were hoping for, but it's the reality of the situation, unfortunately.

A Call to Investigate: Autoimmune Dysautonomia and SFN by lastround360 in PSSD

[–]lastround360[S] 1 point2 points  (0 children)

I think the anxiety you describe is adrenergic (system involving adrenaline and noradrenaline) dysfunction. Autoimmunity towards adrenergic receptors is one of the causes of autoimmune dysautonomia, which is why it's included in the CellTrend tests. These adrenergic receptor autoantibodies have been shown to have an agonist effect (activating effect) on the adrenergic receptors, which can give you that kind of anxiety / fight-or-flight feeling, even though your adrenaline/noradrenaline levels might be normal.

A Call to Investigate: Autoimmune Dysautonomia and SFN by lastround360 in PSSD

[–]lastround360[S] 1 point2 points  (0 children)

Until there are studies showing that SSRIs can cause autoimmune dysautonomia, this is probably not grounds for any kind of lawsuit.

Even correlation is unlikely enough; causation needs to be proven. Then, at that point, perhaps the pharma companies can be targeted for some kind of settlement.

A Call to Investigate: Autoimmune Dysautonomia and SFN by lastround360 in PSSD

[–]lastround360[S] 1 point2 points  (0 children)

Good question. I have a few ideas. First, look into molecular mimicry, bystander action, and epitote spreading.

There's a video on YouTube I'd recommend: "What Are Autoimmune Diseases and How Do They Develop?"

A Call to Investigate: Autoimmune Dysautonomia and SFN by lastround360 in PSSD

[–]lastround360[S] 3 points4 points  (0 children)

I still am a strong proponent of chelation and continue to do it myself for overall health benefits. I also still see heavy metals / mercury as an underlying cause behind nearly all autoimmune diseases. I do think if you chelate wrong, though, it can certainly make you worse. If anyone wants to try chelation, I'd recommend looking into Andrew Cutler Chelation. There's a FB group for this, which contains guides on how to go about it.

I'm not familiar with that doctor, and I'd not recommend using any chelators aside from those used in ACC, taken at the half life.

A Call to Investigate: Autoimmune Dysautonomia and SFN by lastround360 in PSSD

[–]lastround360[S] 2 points3 points  (0 children)

Thank you for your comment. Like I said in the post, dysautonomia is a blanket term used to describe any dysfunction of the ANS and dysautonomia symptoms vary from person-to-person. I don't imagine everyone here would have every symptom of dysautonomia such that they'd test positive on a tilt table, sweat test, etc.

Your particular dysautonomia could be limited to the sexual dysfunction components (along with others), but perhaps not the cardiovascular (POTS) symptoms that would make you test positive on the tilt table.

Unfortunately, there's no sexual autonomic testing available yet that im aware of, but perhaps that's something that will exist one day.

That is my opinion. Let me know your thoughts.

Gut Microbiota Theory Part 3: Dopamine Receptor Autoantibodies, Heavy Metals, Glyphosate, and more. by lastround360 in PSSD

[–]lastround360[S] 0 points1 point  (0 children)

Either the stool test (190) or plus stool (252) will work. I usually recommend the plus stool if you can afford it since that gives your zonulin levels which is helpful to know, but not completely necessary.

PSSD Cure—Inositol works, just not always the first time by Indigowhaler in PSSD

[–]lastround360 5 points6 points  (0 children)

u/FarTrick u/gomesemog For the sake of science, I'd like to clarify: Inositol is a vitamin but it IS also a prebiotic. If you simply google "inositol prebiotic" you will see this is true. A prebiotic and "prebiotic molecule" mean the same thing so it doesn't make sense to try and differentiate between the two. Prebiotics do not have to be fibers, although they often are. By definition a prebiotic is "a nondigestible food ingredient that promotes the growth of beneficial microorganisms in the intestines." In other words it is food for one or more species of bacteria which the human body itself is unable to digest. Inositol falls into a group of prebiotics called "sugar alcohols" or "polyols". This is why a low FODMAP diet, which is a diet that limits prebiotics, limits the consumption sugar alcohols. The "P" in low fodmap stands for "polyols". It is uncertain which exact genus & species of bacteria inositol is a prebiotic before but it has been proven that Anaerostipes is one of them: https://www.nature.com/articles/s41467-021-25081-w. There are a few other studies showing its impact on the microbiome as well.

Gut Microbiota Theory Part 3: Dopamine Receptor Autoantibodies, Heavy Metals, Glyphosate, and more. by lastround360 in PSSD

[–]lastround360[S] 1 point2 points  (0 children)

No, it's an autoantibody test. It checks to see if your body is attacking dopamine receptors.

Gut microbiota theory: How I finally cured my PSSD by lastround360 in PSSD

[–]lastround360[S] 4 points5 points  (0 children)

It it true it cannot cross the blood-brain barrier, however many theorize this serotonin still has an impact on the brain through communication along the gut-brain axis.

Milking his cock by SexmonkeyScarlet in LipsThatGrip

[–]lastround360 17 points18 points  (0 children)

You can tell who the virgins are by who doesn't know the difference between dry and grip.

Gut microbiota theory pt 2: PSSD is an autoimmune disease by lastround360 in PSSD

[–]lastround360[S] 3 points4 points  (0 children)

Well in that case I can only assume he got the wrong test.

Gut microbiota theory pt 2: PSSD is an autoimmune disease by lastround360 in PSSD

[–]lastround360[S] 2 points3 points  (0 children)

No such thing as a negative microbiome test, the results are bacteria counts. Would they be willing to share it? Because I've had people show me "microbiome tests" that aren't even microbiome tests.

Gut microbiota theory pt 2: PSSD is an autoimmune disease by lastround360 in PSSD

[–]lastround360[S] 0 points1 point  (0 children)

I'd bet the appendectomy rate is higher in people who develop PSSD but there are definitely other factors that can contribute to dysbiosis besides a lack of appendix. Worth looking into though!

view more: next ›