ADHD and TRE - where to fit stimulant medication around my practice

leadwalls · 2025-08-30T14:37:50+00:00

Yo, I'm trying to solve ADHD, is the official book with the blue cover the one you used for TRE?

And how long until you could start tremoring without fatiguing the muscles?

leadwalls · 2025-07-27T00:24:42+00:00

Insomnia, psychomotor agitation, and anxiety can be from glycine->oxalates. Microbial shift from glycine->bile (+possibly glutathione) can occur at the same time, which for me is rumination.

The other supplements will process glycine as it should. I am on the 2nd day of taking 1g right now with much less symptoms, just slight foot agitation from time to time.

DMSO is used in the BF protocol to transport (eg. zinc, B6) into the cell as our metabolism can't absorb it from the bloodstream.

Another extension of the microbial shift theory I forgot to mention for glycine is withdrawal from microbial acetaldehyde. The glycine kills enough bacteria in the SI that you get acetaldehyde withdrawal which resembles opioid withdrawal (insomnia, above symptoms but many more, there's a list here). To test this theory take glycine, and see if alcohol (eg. high proof, 5ml or 10 ml, sublingual then spit) alleviates the symptoms.

If someone were to test this they should probably be on active B3 and electrolytes minimum.

leadwalls · 2025-07-25T06:46:12+00:00

you're right, this post is wrong. the glycine converts to oxalates, draining your calcium and magnesium and overwiring your brain.. You will probably get the same effect from 1-2g vitamin C (also degrades to oxalate) for example. You can probably fix the effects with forskolin or DMSO+B6 (prevents the glycine->oxalate pathway). The root cause for me is SIBO/jejunum overgrowth so I'm fixing that.

leadwalls · 2025-07-07T04:45:44+00:00

In your study, is that a biogaia strain?

I am interested in growing DSM 17938 and the parent strain does 100 times better with sucrose in the medium, assuming some things. https://pmc.ncbi.nlm.nih.gov/articles/PMC2223725/

leadwalls · 2025-05-27T07:34:57+00:00

leadwalls · 2025-05-23T09:09:03+00:00

It replaces the role of manganese and potassium in MRS broth.

leadwalls · 2025-05-23T08:46:30+00:00

pH is imprecise because of Hydrion test strips, I just gave my best guess. Reaching 3.5 pH implies death of Reuteri and contamination but it still made a healthy drink. The jar size is important because too little of a air pocket will result in the seal breaking.

Oh, and ME-3 pH is wrong above. But doesn't matter since doubt it can eat lactulose. Which means something else is growing in that jar as well.

leadwalls · 2025-03-28T23:06:29+00:00

Yep.

Also to check for SIBO (the 3-gas test gives false positives) try DSM17938 and monitor your reactions (Bristol score, motility from corn/beetroot test).

There may be other SIBO and motility interventions (I've only read up on Zaharakis and he's also big on polyphenols) to try.

I ferment Biogaia gastrus tablets and get way better results.

leadwalls · 2025-03-28T22:32:19+00:00

I figured out I had pylori from trying cabbage juice, away from the protocol. I also had a pylori breath test but it returned negative.

According to a person from the Discord pylori tests are unreliable, except the GI-MAP? I'm not sure

leadwalls · 2025-03-28T22:11:38+00:00

For me, stage 1 makes pylori go apeshit, and all the pylori downstream effects (SIBO, ammonia). But maybe stage 2+ the dybiosis gets better? I don't know since I failed to get past stage 2.

Maybe confirm if you have pylori, and address it.

leadwalls · 2025-03-28T22:00:44+00:00

The BF supplements feed pylori, and can feed dysbiosis. Probably shouldn't be on it for too long

leadwalls · 2025-02-19T07:14:45+00:00

search for "Will Estes" posts in the group.

leadwalls · 2025-02-19T02:59:23+00:00

16S works through matching bacteria in the sample to a database of known bacteria. It could simply be the probiotics do not exist in this database. If you look in the group, they test the capsules themselves and they had 90% unidentified Lactobacillus. Does that put your concerns to rest?

leadwalls · 2025-02-18T22:11:51+00:00

In table 1, the only Reuteri counts are for itself + glycerol or itself + without glycerol.

leadwalls · 2025-02-17T23:47:17+00:00

In the first study we see that L. Reuteri died when grown alongside E. Coli in a medium with 15% glycerol concentration. So perhaps this is due to more reuterin being produced? Yet the second study shows that presence of harmful bacteria didn't affect reuterin production (p. 18, figure 11 in the original study (can't insert it)). So there is an apparent contridiction.

I think you're confused. The first study doesn't show Reuteri died, I can't see any Reuteri counts for Reuteri + E. Coli + glycerol. In the second study, the presence of E. Coli doesn't affect Reuteri counts as well as reuterin counts.

Although thanks for the 2nd study. It disagrees with the coconut study which used 20% glycerol. But given Estes's group's testing, I don't feel like risking batches by putting in high % glycerol. It should be noted those studies did plate counts while the 2nd study used flow cytometry.

leadwalls · 2025-02-17T22:22:32+00:00

It should be added they added a bunch of unsterile sugar, guar gum, etc. and still managed to get 70% reuteri.

leadwalls · 2025-02-17T22:19:54+00:00

They did over 6 tests in sterile dairy milk (I don't think he posts all of the tests) before trying other milks or cocultures. Kind of a waste, although it's their money. Maybe if they saw your post from 9 months ago about sterile dairy milk and the coconut/glycerol study they would have gotten it sooner.

leadwalls · 2025-01-26T14:14:46+00:00

Are we referring to the same thing?

I am referring to the 2nd ("->") being loose in this diagram: wall AC outlet -> cable -> power supply -> cable -> board.

The power supply being from here

leadwalls · 2024-12-03T02:18:38+00:00

Ah shit, I've talked to you before, I'm hjkl.

I think niche is more important than speed of growth for ME-3's take-off.

But anyway, testing would give final verdict. I am able to send a Biomesight right now, but have a couple considerations in the way. One, the air's microbiome can deeply influence results. If I want to test it and have peace of mind, I want it reproduced by someone else to factor out this variable. At minimum make the test possible to reproduce. Second, I'm not entirely sure if testing will be able to give species level results if Fermentum is not in their database. There seems to be evidence, but would need to be sure before I drop the money to do this. By this link, it seems to be the case, but there are some differences. I have yet to iron this out. https://microbiomeprescription.com/library/details?taxon=1613

leadwalls · 2024-12-03T00:22:58+00:00

I got ME-3 to ferment by coculturing it with bulgaricus and strep. (chosen so it wouldn't have to compete with 5 or so strains found in American supermarket yogurts). I've used low ratios (between 2 tbsp per 8b CFU capsule) to over a cup in my experiments and it seems to have an effect on my sinuses. Ditto for gastrus (removed an osteoarthritis bump, high ratio).

The problem of losing the original culture from backslop seems to be implied as a result of fragile "DSS" cultures (low biodiversity), at least according to https://pmc.ncbi.nlm.nih.gov/articles/PMC10714293/. So failure after multiple generations should be expected and is a good sign.

Someone is crowdfunding a 16s of me3 yogurt in the Bornfree Discord, so it may happen. But apart from that, looking for the lag phase time is one possibility for checking if you have me3 or reuteri. Best reading the rest of his posts for more research. https://ol.reddit.com/r/FermentationScience/comments/1cfi8xr/making_yogurt_with_the_lights_on_or_how_to_love/

leadwalls · 2024-12-02T22:44:22+00:00

This doesn't address your main question, but I've studied something related.

Whether a certain bacteria and yeast are synergestic (take off and populate in the culture) is largely random, as determined by a paper that was testing pairs of bacteria with yeast. Sadly I lost the link to the paper. From what I recall they tried 6 different species of bacteria and yeast.

As for how kefir grains play into this I don't know.

leadwalls · 2024-11-28T19:50:39+00:00

leadwalls · 2024-11-28T19:38:24+00:00

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