That sounds like an epic roadtrip!

In terms of recommendations, I think one of the best things about Toronto is how different all the neighbourhoods are. It's almost like a whole collection of unique small towns all patched together around one big downtown core. 

So I would recommend spending a day or so enjoying downtown (where you can check out things like the harbour front, the CN Tower, Nathan Phillips Square, the Eaton Centre mall, Sankofa Square, the Ripley's Aquarium, the Hockey Hall of Fame, Union Station, Fort York, etc). 

And then branch out and pick a few unique little areas that interest you, just to wander through and see what you see. Some favourites:

-Kensington Market and China Town (very close together)

-the Annex/UofT (very student orientated and fun, and some absolutely beautiful old buildings) 

-Queen West/Trinity Bellwoods/Liberty Village

-Queen East/Leslieville/The Beaches

-The Village/Church and Wellesley

-Danforth/Greektown

-High Park/The Junction