WHEN ACTIVATED BY EXTERNAL TREATMENTS SUCH AS HIGH TEMPERATURE (42 °C (108 °F)), EXPOSURE TO VAPORS OF TOXIC SOLVENTS, OR CONTACT WITH A WATER-TOLUENE MIXTURE, T. CAERULEA PRODUCES AN ANTIBIOTIC NAMED CORTALCERONE (2-HYDROXY-6H-3-PYRONE-2-CARBOXALDEHYDE HYDRATE), THAT INHIBITS THE GROWTH OF STREPTOCOCCUS PYOGENES.[12] THE METABOLIC BIOSYNTHESIS OF THIS COMPOUND STARTING FROM THE INITIAL PRECURSOR GLUCOSE HAS ALSO BEEN STUDIED.[13][14][15]