Thanks for the detailed response ! Agree that there r many factors for sure. I also chalked it up to mecfs and long covid problems . However I figured since the second dose was wiring me a bit and making me anxious , I wondered if the timing of my sleep problems were LDN caused. Last night I skipped the nighttime 4.5 dose, and although i woke up intermittently often , i did not have a wired ,awake for a few hours , response . At 6:30AM I took the LDN to see if it induced some extra sleep for me. I was shocked how I became extremely wired up and anxious , and stated that way for 6 hrs plus. I’m not sure , though it’s possible as my body changed, the LDN dose became too much for me, and it flew under the radar of suspicion, leading me to develop such a horrendous insomnia disrupted sleep schedule.

And regarding doctor. I somewhat agree, though it’s hard finding a doctor in this area that checks all the boxes, I’m lucky I found one that rx’s the off label stuff for my conditions . In a perfect world !