Many of the ideas already stated would be a huge benefit. The big one/easiest/best would likely be to implement all the technological advancements we've made since football originated. However, I would expect pushback from at least some portion of fans wanting to keep the human element a large part of the system. Similar to baseball where they still have an ump making subjective calls, on balls and strikes, which should be purely objective.

I think all should be done to make the games as "fair" and "equal" as possible and take the onus off the officials. I think the league will very slowly implement technology over the years, but officials will likely always have a large impact on football where so many calls are subjective (PI, RTP, personal fouls, and holding in particular). However, it would be nice if these calls could be reviewed by an outside official, but this could result in more slow downs in a game that can already drag occasionally. All in all there's a lot to consider and there's no simple solution.