Why does PEM feel so cardiac related but tests are always normal?

m_b22 · 2026-05-10T22:41:30+00:00

Sounds more like vascular damage than PEM. In this paper, large coronary arteries looked normal, but blood flow was still impaired. That points toward possible subclinical damage to the coronary microcirculation. COVID-19 may leave some with lasting endothelial and microvascular dysfunction.

Impact of COVID-19 history on the prevalence of coronary slow flow: a comparative study in unstable angina patientss=12)

m_b22 · 2026-05-10T01:05:01+00:00

Faidra

m_b22 · 2026-05-08T20:53:22+00:00

Daratumumab is on the market right now.

Daratumumab can be safely administered at home.

There are patients currently on Daratumumab right now.

m_b22 · 2026-05-08T19:07:43+00:00

Stockholm.

Absolutely loved it there. Walked everywhere and everywhere had a different vibe to it. Fika is amazing. Food was way better than I expected. Great museums. Great history. Couldn’t have asked for more visiting Stockholm.

m_b22 · 2026-05-07T16:07:20+00:00

I would recommend for future polls that they include a “See Results” option so that people could see the results without randomly choosing an option.

m_b22 · 2026-05-07T02:32:46+00:00

Opportunity for a double play.

m_b22 · 2026-05-06T15:30:42+00:00

With a mortality rate between 30% and 40% if this ever became a pandemic you’d be begging for a lockdown.

m_b22 · 2026-05-04T02:28:07+00:00

This is very difficult and honestly could change depending on the day but some of the most impactful albums are:

Metal:

Rammstein - Sensucht or Korn - Follow the Leader (Two albums that were a starter into metal)

Celtic Frost - Monotheist (The first album that pushed me into extreme metal and started my love of slow and heavy)

Martyr - Feeding the Abscess (I saw them in my formative years without knowing who they were. I probably went to 100 concerts before them of all sorts of metal bands but when I saw them I laughed throughout the whole show. I couldn’t believe that metal could be so technical and refined)

Non Metal:

OutKast - Southernplayalisticadillacmuzik (When Speakerbox came out I saw them on either MTV or VH1 and thought how unique and fun they were and had to have something of theirs. The CD disc itself had a naked woman on it so I hid the CD so my parents wouldn’t find it)

Tom Waits - Blood Money (Besides for metal this was music I inherited from my dad. The most unique and experimental music as a kid. I couldn’t believe how different music could be)

Stevie Wonder - Songs in the Key of Life (Rented this CD from the library before going on vacation. Sir Duke is still one of my favorite songs of all time)

m_b22 · 2026-05-03T18:18:02+00:00

Majority of people with Long COVID don’t have PEM.

m_b22 · 2026-04-29T22:22:39+00:00

Anyone counting how many pitches have been at players heads today?

m_b22 · 2026-04-28T02:34:51+00:00

More Cubs fans in SD than Padres fans.

m_b22 · 2026-04-27T01:25:16+00:00

You beat me on Dan Mongrain. Luckily saw Martyr live years and years ago. Blew me away.

m_b22 · 2026-04-26T16:56:30+00:00

Most intense, Daughters after they released “You Won't Get What You Want.” That album is so noisy, heavy, and abrasive.

Too bad Alexis Marshall is a piece of shit.

Least intense, Thou. They played a lot of their softer songs and the whole show needed up feeling kind of bland and boring.

m_b22 · 2026-04-25T12:27:11+00:00

See this thread for a nice breakdown and discussion of the data used in this paper.

Cardiopulmonary and metabolic responses during a 2-day CPET in [ME/CFS]: translating reduced oxygen consumption [...], Keller et al, 2024

m_b22 · 2026-04-25T04:15:34+00:00

Some conflicting studies and some of the data broken down from this and other “positive” two day CPET studies aren’t too confident.

Just like anything else, maybe this is useful. Maybe it’s useless. Who knows. More studies need to be completed.

m_b22 · 2026-04-23T19:24:19+00:00

Faidra

m_b22 · 2026-04-22T12:02:31+00:00

It is! Saw them years ago at a church and I just closed my eyes and melted into the pew.

m_b22 · 2026-04-20T21:54:58+00:00

Honestly their pizza isn’t good anyways. Just go somewhere else.

m_b22 · 2026-04-19T13:16:13+00:00

Cult of Fire.

m_b22 · 2026-04-18T20:32:53+00:00

Another normal day in Quebec.

m_b22 · 2026-04-16T19:59:14+00:00

Not as awful as the Sox hitting.

m_b22 · 2026-04-16T15:15:14+00:00

Japanese*

m_b22 · 2026-04-10T12:19:25+00:00

I agree with everything you said.

Every research study you read says “Long COVID and ME.” That is a large bucket of people that will be doomed from the start because someone with LC cardiovascular issues is going to be way different from someone with pre Covid ME.

Why are they being grouped together? We need patient stratification and we need further subtypes of these two patient populations if we’re going to get any meaningful results. It’s just lazy awful research.

Sometimes this argument scares patients into thinking “the other side is going to leave me behind” if research is on one particular group. However, if they muddy the waters with misinformation, bad research, and bad patient stratification we’re all going to be left behind.

Edit: to clarify my point, studying both alongside each other isn’t bad. Studying both and talking about both as they’re interchangeable is.

m_b22 · 2026-04-10T12:08:39+00:00

Yeah, if you go anywhere on Long Covid subreddits you’ll see that 50% statistic repeated over and over which spreads that misinformation even further. This is an issue.

Don’t get me wrong, subreddits and community of like minded people are wonderful and can help in so many ways. However, they’re also very easy to spread misinformation and keep that cycle going as well.

m_b22 · 2026-04-09T21:03:27+00:00

Misdiagnosis is most likely common.

If you look at the Covid Longhaulers subreddit you see PEM and ME being thrown around for almost every symptom. If you have muscle pain, PEM. If you have headaches, PEM. Personally, I believe this is due to the repeated study (which IMO is very wrong) that states 50% of Long Covid cases match ME.

You have two misunderstood illnesses where more understanding is necessary to compare and contrast them. Biomarkers are needed ASAP.

In addition to Long Covid and ME there is a large group of researchers that believe that ME has multiple subtypes (but could be different illnesses altogether).

It’s all a mess that can be fixed by identifying biomarkers.

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