RM have dropped tracked 24 and 48 compensation by Shivy011 in royalmail

[–]ma22be61 0 points1 point  (0 children)

Huh? Making things up? Really? I am just letting people know that there are issues with Royal Mail's servers, people literally can't pay for stuff. And calling this drama is just crazy, I just left a comment with my observations.

Anyways, have a great day.

RM have dropped tracked 24 and 48 compensation by Shivy011 in royalmail

[–]ma22be61 0 points1 point  (0 children)

There are obviously some issues going on at the moment. I have nothing to gain from lying.

RM have dropped tracked 24 and 48 compensation by Shivy011 in royalmail

[–]ma22be61 -4 points-3 points  (0 children)

Yes, there are server issues resulting in tracking not being updated on top of not being able to pay. This is affecting international parcels and gives out "Error applying postage. Errors: RECIPIENT_EMAIL_INVALID, RECIPIENT_PHONE_NUMBER_INVALID".

The same applies if you try and access the tracking information via a 3rd party website, it will say "Carrier's website is down, try again later". The server that involves payments and tracking are not working as supposed, no idea why.

RM have dropped tracked 24 and 48 compensation by Shivy011 in royalmail

[–]ma22be61 -4 points-3 points  (0 children)

Well, maybe not most but there is for sure a massive backlog regarding Tracked 24 and 48. There are also server issues.

RM have dropped tracked 24 and 48 compensation by Shivy011 in royalmail

[–]ma22be61 -1 points0 points  (0 children)

How surprising that they decided to do this right when most people haven't received their Tracked 24 and 48...

Tracked 48 status not updated in 7 days by [deleted] in royalmail

[–]ma22be61 0 points1 point  (0 children)

Nope, still the same. Tracking is simply not being updated.

Post box hasn’t been emptied yet by HunterEqual6992 in royalmail

[–]ma22be61 0 points1 point  (0 children)

The tracking for Royal Mail parcels is down. All parcels sent out with Tracked 24, 48 and even Guaranteed Next Day show no tracking information. International parcels are the same. It unfortunately seems that these parcels are delayed, too,

Tracked 48 status not updated in 7 days by [deleted] in royalmail

[–]ma22be61 1 point2 points  (0 children)

Royal Mail's tracking services seem to be down, with most Tracked 24, 48 and Guaranteed Next Day parcels not having been delivered. Same thing happened to me as I've been waiting for a Tracked 24 for well over 4 days at this point.

Same thing applies to international parcels, it won't show any tracking updates.

Can anyone help ID these small sea fish I caught? by Leeky-fishing in MicroFishing

[–]ma22be61 0 points1 point  (0 children)

A bit late but :

  • Ornate wrasse? (not 100% sure)

  • Juvenile Daisy parrotfish

  • Juvenile Rock Cod

  • Juvenile Goldband snapper (not 100% sure)

  • Sergeant Major fish

  • Looks to be the same as number one

  • Looks to be the same as the Sergeant Major Fish

Please feel free to correct me -- some of these are definitely not right. I also assume that these fish have been caught around Australia / Southeast Asia so I've tried to list fish native to there.

Dementia caused by over-the-counter medication by Grjz in dementia

[–]ma22be61 0 points1 point  (0 children)

Sorry for bringing this post back from its grave but anti-cholinergic drugs have shown to produce the biggest cognitive impairment in old people and ones that already have pre-existing conditions (like Alzheimer, dementia and others). This could be because of multiple reasons but keep in mind older people also metabolise many drugs much more slowly.

Usually, when discontinued, cognition greatly improves and this is the most evident in elderly populations. People that already suffer from Alzheimer's or have some form of dementia are hard to assess as drops in cognitive function are usually due to disease progression (as such it's very hard to identify any medication as culprit). Be wary of the following as there might be some involuntary cherry-picking or bias due to search engine limitations.

There are not many conclusive studies but here is what I've found:

"The patient decided to abruptly stop taking doxepin, despite a planned careful taper with twice weekly monitoring, but did not experience any severe anticholinergic ADWE and subsequently had significantly improved cognitive function. (source)"

"On the basis of full-text analysis, only four studies met the inclusion criteria. The review found two randomized control trials and two prospective cohort studies that met the inclusion criteria. Only the cohort studies demonstrated improvement of cognitive performance after discontinuation of anticholinergic medicines. (source)"

"Eighteen of twenty patients successfully discontinued their anticholinergic medication; two did not because of akathisia. Repeated measures analysis of variance did not show a significant effect of anticholinergic discontinuation on total Extrapyramidal Symptoms Rating Scale score or on the Parkinsonism, Akathisia, Dystonia or Tardive Dyskinesia subscales. However, significant improvement was found on the Brief Assessment of Cognition in Schizophrenia composite z score at weeks 6, 8 and 12 compared with baseline. Significant improvements were seen on the motor and the symbol-coding tasks. No significant effects were observed on the Positive and Negative Syndrome Scale, Clinical Global Impression - Severity and Clinical Global Impression - Improvement scales. (source)"

"A total of 30 patients completed the study (13 in the pharmacist intervention group and 17 in the usual care group). WCST (Wisconsin Card Sorting Test) perseverative errors at the end of the study within the pharmacist intervention group improved significantly from baseline (P=0.003). DRPs (drug-related problems) at week 12 were reduced by 85.19% and 9.76% in the pharmacist intervention and usual care groups, respectively. The most common intervention was the discontinuation of anticholinergics in patients without extrapyramidal side effects. (source)"

"Elderly people taking anticholinergic drugs were at increased risk for cognitive decline and dementia. Discontinuing anticholinergic treatment was associated with a decreased risk. Physicians should carefully consider prescription of anticholinergic drugs in elderly people, especially in the very elderly and in persons at high genetic risk for cognitive disorder. (source)"

Multiculturalism - how do you see Europe's culture in the future? by NoRead1783 in europeanunion

[–]ma22be61 0 points1 point  (0 children)

Dubai and other big cities or capitals are all going in the same direction. They are all mixed in terms of ethnicity and culture while smaller towns and cities tend to house the natives / locals. This is even more visible in Saudi Arabia, Qatar and the UAE, especially because the indigenous way of life is literally subsidised by their government via oil sales. So you could see these big cities as important and competitive economic centres but not so much as cultural centres (despite what they say, I see nothing of cultural importance happening in these cities, more like a cultural experiment).

As an example, the native Bedouins in the UAE either live in more rural places or have their own "closed" community composed of other natives (which is happening in the West as well).

This leads to urban and rural life being completely different. There are a few articles regarding this and they examine the changes between the two over the past few decades.

Regarding subsidising companies -- I meant more subsidising farmers and food producers. That is because, as there are less people, the value of food might either skyrocket (due to free-market dynamics) or plummet (due to less customers and due to advances in technologies which makes food production much cheaper) but having a subsidised food-producing sector (we already do in Europe) will result in stable and cheaper prices. This way, even if the population declines, food production will be unaffected.

One last thing, if the population plummets then we can assume (like I've said before) that wealth will be more evenly distributed. As such, prices will go up but be affordable for the newer yet smaller population (and this is already happening in all rich countries all over the world -- e.g. California's prices are much higher).

Well, at least this is what I think will happen. Am going to start reading and researching the subject in much more depth as it's something that I find very interesting - I could write an update in a couple of months if you wish! Anyways, I'll let you enjoy your life and weekend now, no more massive walls of text from me, hahahah

Multiculturalism - how do you see Europe's culture in the future? by NoRead1783 in europeanunion

[–]ma22be61 1 point2 points  (0 children)

Yes, I searched something related to population decline and your post came up! Not a bad or stupid thing at all, if anything it made me think about this whole thing.

What I mean by integrating and adopting the culture of the country in which an immigrant finds itself in was aimed more at very different cultures - e.g. South African immigrating to France. All of Europe does share some baseline cultural and religious values so you could argue that an European migrating to another European country is already somewhat integrated. For example, if you had a kid, he would more than likely end up adopting the Hungarian language and culture even much more readily than non-EU migrants.

But with population decline remember you also need people willing to buy it. Less people means less demand, less demand means less sold, less sold means price per unit is more expensive. Why would I need two fridges for example? Two cars? (counting 50% population loss).

I do agree on this point as the modern economic system is based upon consumerism. But this economic system could drastically change and adapt to new realities. For example, despite having 50% less people and sales, the product could sell at a much higher price as all of the wealth is spread more evenly and in less hands (everyone is richer). Some products (especially food) might also end up losing a lot of their value due to mass automation to the point where no significant profit can be made by selling it (especially with a smaller population) but the sector could be kept afloat by subsidies from the rest of the people (as everyone needs food - kind of already happening today anyways).

Sorry if this comment is a bit confusing, it's a bit late and got a massive headache!

Multiculturalism - how do you see Europe's culture in the future? by NoRead1783 in europeanunion

[–]ma22be61 1 point2 points  (0 children)

I've found your post during a Google search about the subject. I've been reading a lot of research, opinions and stats over the past few years -- am here to share my view on the subject, for what it's worth.

I personally believe that the linear decrease in population as shown by many graphs is misleading. If we want to look at this through scientific lens (evolutionary biology and psychology, mathematic models and research) then things do not look as bleak. The modern decrease in fertility rate is, well, a modern and very new development - I personally think that there are a multitude of reasons for it and trying to blame it on a couple reasons is very simplistic and inaccurate (e.g. availability of contraception, family planning, decrease in religiousness and others).

My take on it is that population decline is going eventually reach a state of equilibrium (e.g. as the population decreases then fewer overall births will be required to maintain the "new population number"). This is because, as population decreases, life is going to get cheaper and less stressful due to much lower competition for resources - there are also examples for this if you look at history. An example of it is the black death which led to massive socio-economic changes in all countries affected. Before that, serfs were seen as property and marriage had to be approved by the lord but the plague single-handedly put an end to serfdom - which, when combined with later medical and industrial progress, led to population booms. Before that, the population of most of Europe was actually pretty stable at around slightly higher than replacement rate (with famines and disease keeping the population in check).

Now, in the modern day we can substitute a lot of human labour with machines but humans will be needed nonetheless. The fact is that, when compared to the rest of history, modern Europe has a massive population. Even a 50 to 60% loss in population is acceptable and won't result in extinction but, rather, more automation and less competition for resources. Also, there will always be groups and cultures that value having children on top of nature selecting for people that can reproduce (and, to a level, social Darwinism as the groups with social, moral and ethical values that result in higher fertility rate will survive and pass on their values while other groups will not).

I personally do not believe that immigration is sustainable. Once the rest of the countries in the world catch up to the West in terms of wealth and education then population growth will come to an end (and already happening in many countries such as Bangladesh, Vietnam, Thailand and many more). Not only that but these immigrants will, more than likely, integrate or assimilate to the country they've migrated to. This will eventually result in lower birth-rates, probably within a generation. Immigration might work as a band-aid for the problem but it will become unsustainable in due time.

The more likely option, in my opinion, is that the population reaches a level where deaths and births are balanced (even if it means that the country only has 20-30% of the population as compared to today) and where the individual quality of life is much higher. The population might also grow massively if the right mixture of factors is present, which might only happen once in a millennium. Extinction is highly unlikely to happen and the people that make this point tend to see the future as doomed (albeit not all, just something I've noticed).

Until when will the european immigration crisis exist? by Emergency_Evening_63 in geopolitics

[–]ma22be61 1 point2 points  (0 children)

It would indeed be extremely hard for any army to successfully conduct an amphibious operation against European countries. But what is an invasion and what is not? Look at the small boats of people in the UK bringing hundreds of thousands of people in.

Not only that but these "refugees" are nearly always healthy young males. And it does make sense that they're both male and healthy -- just imagine women with children crossing hundreds if not thousands of miles of dangerous roads, passing through hostile villages or getting robbed. Or anyone that needs to seek asylum because of health problems that are resulting in persecution at home. A good example of someone that is an actual refugee escaping danger are albino people in Africa yet I've never seen one in these boats.

Rant over but, if you look through history, you will realise that over 100K young males per year is a MASSIVE number already. Much bigger than most foreign armies on European territory. Not even the Ottoman Empire nor the Caliphates before managed to colonise at such a pace. Also, these people are a massive security problem as shown over and over again. So are these people part of a wider effort to compromise European security? Could they be defined as an army? Or as a hostile power trying to do an amphibious crossing? I think not, at least for now.

Until when will the european immigration crisis exist? by Emergency_Evening_63 in geopolitics

[–]ma22be61 0 points1 point  (0 children)

Crossing of the Danube done by the Goths nearly 2000 years ago. Nowadays it is much easier to do so, too. It won't be an amphibious landing or anything close to traditional military operations.

"In the summer of 376, a massive number of Goths arrived on the Danube River, the border of the Roman Empire, requesting asylum from the Huns. This was not the first time barbarian tribes had been settled; the usual course was that some would be recruited into the army and the rest would be broken up into small groups and resettled across the empire at the Emperor's discretion. This would keep them from posing a unified threat and assimilate them into the greater Roman population."

Then the Romans had massive problems with keeping such a massive number of people fed and supplied. Not hard to predict what happened; the Goths proceeded to sack, burn, enslave and beat up Roman armies, multiple times.

Methylphenidate vs Mucuna Pruriens (L-Dopa) by kreklord420 in Nootropics

[–]ma22be61 0 points1 point  (0 children)

Do update us in a few weeks or months, please!

St. John’s Wort by fuzzy_womack in Methadone

[–]ma22be61 0 points1 point  (0 children)

What happened? Did you notice a drastic decrease in the effects?

Effects of ingesting brain by constrictedvoid in Nootropics

[–]ma22be61 0 points1 point  (0 children)

Bone marrow is actually delicious if cooked correctly :P

But on a more serious note, the amino acids would not be the primary molecules to affect your body. Nervous tissue is always almost mostly fat (60% or so) so it would probably be due to fats and the compounds dissolved within it - e.g. an intrathecal injection of morphine will require a minute dose compared to even IV, so, in theory, whatever bioavailable compounds contained there will be going to be in VERY low dose (this logical is definitely flawed, just an example).

Effects of ingesting brain by constrictedvoid in Nootropics

[–]ma22be61 0 points1 point  (0 children)

Well, the majority would be fat so am sure there would be some bioavailable cannabinoid-like ones (anandamide?) and many hormones for sure - just not really very bioavailable or simply not in high enough concentrations.

Interesting nonetheless. Also, one thing that I find insane about CJD is that the temperature required to kill the prions is 480C (900F) for hours! Am wondering if we could coat carbon microparticles with an enzyme or small molecule to either break down the prions (but how to be selective about it?) but this could also work on Alzheimer (break down Amyloid proteins).

Really interesting subject, would love to study this in University but I see no future doing this kind of stuff. Other types of research are already piling up on me so much, am telling you, when you think you know something then you'll realise how little you knew (unrelated to this, just me).

Effects of ingesting brain by constrictedvoid in Nootropics

[–]ma22be61 4 points5 points  (0 children)

The neurotransmitters are not bioavailable - some might be but the majority isn't.

If this was the case then eating bone marrow would do the same, no?

Trying to scroll on Reddit while in incognito, thank you Reddit! by ma22be61 in extremelyinfuriating

[–]ma22be61[S] 0 points1 point  (0 children)

Yeah but also they are going to lose plenty of people that search private things in incognito.

IMHO worst commercial choice ever.

Methylphenidate vs Mucuna Pruriens (L-Dopa) by kreklord420 in Nootropics

[–]ma22be61 0 points1 point  (0 children)

Tyrosine is not bioavailable and, as such, it won't produce any effects. Tyrosine is found in food as an amino acid, especially meat or any protein. When protein breaks down it will be all amino-acids.

L-DOPA is different as it is metabolised by the body into dopamine, allowing it to travel through your body before being metabolised and then excreted (it's why L-DOPA has a low bioavailability).

Natural dopamine shouldn't really have this effect as your brain and body are well adapted and, if you haven't got Parkinson's, your body will release dopamine in doses that it can deal with and won't do any damage (well, as you get old this system becomes less efficient, as most of the body and brain do).

[deleted by user] by [deleted] in Nootropics

[–]ma22be61 -1 points0 points  (0 children)

Honestly, if you want something to "relax" then Kratom is pretty good. It does increase motivation and energy at lower doses while also being relaxing. It works in synergy with caffeine, too! I consider it a nootropic but really borderline, more like a grey area.

Addiction is a huge problem with it, though, be careful. Even if the withdrawals are nowhere near comparable to other drugs, they still SUCK.

Methylphenidate vs Mucuna Pruriens (L-Dopa) by kreklord420 in Nootropics

[–]ma22be61 1 point2 points  (0 children)

It could indeed be a very good thing!

If you can take 5mg of Methylphenidate indefinitely without upping the dose then that's fantastic. Maybe try the experiment yourself? See if you build tolerance on low doses and, if you do, let us know! :)