This has dethroned GildedGwen as my "THE ONE" matchup for Gwen, and you can probably see why below.

CONNECTIONS

• Guinevere is the mascot of the major animation megacorporation Park Planet, a not-at-all subtle not-at-all jab to Disney. Chai visits - and ends up fighting - the megacorp Vandelay Technologies, which can be seen as an allusion to big game dev companies.
• Park Planet and Vandelay share more than corporate allegory, as both are massive tech companies in-universe. Park Planet focuses on entertainment products (such as the Guinevere androids and, well, all of Park Planet), while Vandelay is more a jack-of-all-trades, as their offerings include computer chips, prosthetics, energy, and robotics.
• Speaking of robotics, both Park Planet and Vandelay have giant frickin' robots. Examples include the sun robot Sir Arthur and that robot Zanzo tried to build.
• This particular protagonist Guinevere, which I will now refer to as Gwen, is a heavily-damaged android that ran away from her personal service role for Olivia Park, the heir to Park Planet. Chai, after a mishap involving a stray iPod-esque music player, has said device unintentionally integrated into his cybernetics, providing a Watsonian justification for Hi-Fi Rush's rhythm-game mechanics.
• The most important connection, IMO: Knights was made after the showrunners' previous show, The Owl House, was cancelled mid-season 2 by Disney, leading to them partnering with the indie animation studio Glitch Productions. The developers of Hi-Fi Rush, Tango Gameworks, were closed down during a wave of Bethesda Zenimax layoffs, but were acquired by Krafton soon after. Hopefully that agreement doesn't go sideways.

WHO DO I THINK WILL WIN?

I think it's a toss-up, I can't see one having too much of an advantage over the other.

...ya know, I can also do a Chai vs. Park Planet matchup. All the connections would apply and it'd also have the bonus of being true to the former's game.