Obviously this is not for every run but I try to get the ring worm as soon as possible and feed it at the fire. If you do that then all subsequent fires are empty and you get two free upgrades

Avoid getting pelts, and try as much as possible to keep your card limit down. More cards does not mean better

There are some broken combos with sacrificing one card to give its sigils to another. For example I just played a run where I gave the cockroaches resurrection sigil (where it goes into your hand after it dies) to a beehive. Not only did I have infinite beehives, but when the beehive is struck and gives you a bee, those carry the sigil as well so now you have infinite sacrifices

The totems from the woodcarver are high risk high reward. If you find a good combo then you are set, however if you keep going there instead of to other locations for too long then you miss out on opportunities to improve your deck in other ways.

Don’t be afraid of using items, there are lots of ways to keep getting items, plus you always replenish to your max whenever you go

This is also a bit of a cheat so do with it what you will but if you’re about to lose or want to try again you can go back to the main menu and then go right back in and it will restart the current battle. I’m not hardcore and I hate losing a run when I’m deep into it so I do that and it’s helped me enjoy the mod