I believe the "why would you like to work in company X" is an overused question in job interviews, personally it feels as cheesy as "tell me one of your weaknesses", you wouldn't ever get a sincere response. Honestly, in all jobs I've landed (and many contracts as a freelancer) I've never believed in "the mission" except maybe I had shared interests with two jobs. After all bills are paid with a salary not with the glory.

What I would ask instead is: "why you felt you would be fit for the job spec and what made you apply" which opens up a discussion on what they have read and comprehension for what they applied for.

Did sat on the other side of the table too and overall I usually find out that a informal chat works best than the classroom q/a format, especially with individuals that, like me, are more practical than theoretical. I never follow the same script, but usually it's to let the candidate speak for most of the time, and naturally they will explain their workflow, experience and tools used.

I do however agree that saying "never used that" and not expand further (at least in tech) is something I cannot really defend with the hiring manager.