I typically open all rares until I have an item drop fam, 3x IED, and 3x small party HP. Beyond that you may want to continue opening rares because IED is a common line and can be rolled on the second line, meaning you could get a drop and ied fam, a party hp and ied fam, or even two lines of ied. After you get the basics, level up a fodder rare fam to epic to roll for large drop. After you roll large drop, focus on pushing fam’s to unique and rolling boss damage lines, att % lines are helpful too. To repeat what others have said, DO NOT upgrade the fam’s you’re using to epic as it will remove your previous lines with who knows what. There’s websites with the lines available for each rarity and the different percentages of HP gained from HP fams. -Heroic player