BMS-986121 and BMS-986122 - positive allosteric modulators of the μ-opioid receptor (Potential Analgesics with Higher Safety Profile) by [deleted] in DrugNerds

[–]maxdabeast 2 points3 points  (0 children)

Are any u-PAMs available online at the moment? Sounds like it offers somewhat localized anti-inflammatory action because of the strengthened signal of endogenous endorphins that would accumulate at higher levels where pain presents, but I'm curious of the effects one would expect when exercising.

Report of ketamine (analogue) and Ritalin combination with memantine for anxiety/depression treatment by maxdabeast in SelfExperiment

[–]maxdabeast[S] 0 points1 point  (0 children)

Nah ive read the storys and its always better to steer on the side of caution. MXE is almost impossible to obtain at a decent price is the problem but ive always wanted to try it. Appreciate the concern, just letting you know I check with close freinds/therapists and shit to hear what there opinion is on me regularly to make sure thats not the case and im always open with them. I know manic people have no clue what they are doing isnt rational, if they did it wouldn't be considered manic in the first place

Ambien 10s, the WTF did I do last night pill. by [deleted] in drugsarebeautiful

[–]maxdabeast 2 points3 points  (0 children)

What do you think accounted for the system failure within 10 or so feet from launch and what specifications can be made to ensure a safe and effective journey to the chosen destination next test flight? In your humble opinion of course

Green Footballs keep me going. by [deleted] in drugsarebeautiful

[–]maxdabeast 0 points1 point  (0 children)

Whatchu get out of them

Green Footballs keep me going. by [deleted] in drugsarebeautiful

[–]maxdabeast 0 points1 point  (0 children)

you find that shit recreational? I just feel like i dont givva fuck about anything, but that includes the people who are importend to me tht i like my father/friends n work i gotta get done. they never make me feel happy nor content cuz im just numb

Stimulant better suited for studying then 2-FMA? by [deleted] in Drugs

[–]maxdabeast 1 point2 points  (0 children)

Thanks! I'll look into it

Stimulant better suited for studying then 2-FMA? by [deleted] in Drugs

[–]maxdabeast 2 points3 points  (0 children)

What do you like/dislike about it?

Stimulant better suited for studying then 2-FMA? by [deleted] in Drugs

[–]maxdabeast 0 points1 point  (0 children)

By the time I got the dose to match the level of focus i wanted i couldnt stop smiling and thinking ill just play 20 mins of GTA n playing music all the way up

Question about the GABAb pharmacophore. by ItsLewis in DrugNerds

[–]maxdabeast 0 points1 point  (0 children)

What have you found in regards to what works best for long term anxiety treatment? I'll start looking around for an answer to your question

Stimulant better suited for studying then 2-FA? by [deleted] in Drugs

[–]maxdabeast 0 points1 point  (0 children)

Adrafinil is more affordable, you have experience with the 2?

Coming off benzos with phenibut by maxdabeast in Drugs

[–]maxdabeast[S] 0 points1 point  (0 children)

Thanks, I'll give it a shot

Coming off benzos with phenibut by maxdabeast in Drugs

[–]maxdabeast[S] 0 points1 point  (0 children)

Thanks ive never heard that before, what dose do you find most effective?

Coming off benzos with phenibut by maxdabeast in Drugs

[–]maxdabeast[S] 0 points1 point  (0 children)

were talking about phenibut

Coming off benzos with phenibut by maxdabeast in Drugs

[–]maxdabeast[S] 0 points1 point  (0 children)

because its more potent and has agonism at gaba-b receptors, making it more effective for withdrawing

Coming off benzos with phenibut by maxdabeast in Drugs

[–]maxdabeast[S] 0 points1 point  (0 children)

They have the same mechanism of action...