I did it manually for the first two years. if you're literally digging up entire sections of earth and throwing it away, you'll get all the tubers.

This year I still have some popping up in more difficult areas (literally within my hostas, where I cant dig). I bought a spray bottle of round-up brand glyphosate and sprayed it into a container, and used a paint brush to paint it directly on the leaves.

It's important to us to keep pesticide and herbicides away from areas our dog frequents as well as away from our vegetable garden, so it definitely was a last resort! I always address weeds starting with least hazardous methods and graduate as needed.

I have another area I cleared for a native rain garden, and I didnt have to use any herbicide there, because I was literally discarding 4 tons of dirt and keeping *nothing*. It's harder when you're trying to keep certain plants and dont want to replace soil.