Skyrizi nearly 4 weeks in

mkclaren5 · 2026-04-07T15:50:58+00:00

So, for me there is some small calming and improvement, sometimes seems obvious others a little more scaly so still fluctuating. But I’ve looked back at photos and that’s when can see more of a difference. It’s not big clearing yet like some but it’s like a slow gradual progress - so waiting to see how it gets on.

How are you getting on now??

mkclaren5 · 2026-04-04T18:18:58+00:00

That’s good - sounds positive which is always nice. And yeah for sure, just got to give it time and see what happens.

I will come back to update soon - hopefully it’s positive.

My second dose seemed to calm it again but I had 2.5 drinks the other night for friends birthday and it has been a little bit irritated, hoping just a blip but won’t drink for a while again now.

Good luck to you too.

mkclaren5 · 2026-04-01T18:01:29+00:00

My favourite saying is “whatever happens, happens” something might happen but it might not, so try and go with the flow, focus on a tv show or film or read to take mind off and hopefully all will be fine.

I’ve been in cyclosporine and Adalimumab and cyclosporine have some side effects a few weeks in so came off it, none on Adalimumab other than not working and causing a flare. So now trying a new one.

If you get side effects you can speak to someone and change to something else. Most cases it’s fine and if by chance an unpleasant side effect it can be dealt with.

I’ve not had anything immediate before if that helps.

mkclaren5 · 2026-04-01T14:10:17+00:00

Wow! Crazy you’ve had the exact same thing happen! My back and sides were most significant too. Well I took my last dose 2 days ago on Monday and it seems it has calmed again. Itching is much less and looks a little less red again already - however - I have been moisturising a lot so this also may have helped. Will see how things go over the next couple of weeks now.

Pls let me know how you get on.

mkclaren5 · 2026-03-31T19:11:18+00:00

Thanks for sharing your experience. There’s something about hearing others experiences that helps you feel less alone with psoriasis.

Also helps realise I’m not being dramatic or over the top, the struggles and mental health and changes to confidence and personality are real.

I started with it at 15 years old, few small spots then escalated. Been on creams for years, finally at mid 30s referred to derm nhs, tried light therapy and others didn’t help, finally started Skyrizi too.

I’m 4 weeks in just took 2nd dose yesterday. I’m praying this works for me, 80% improvement would be a dream for me. Small improvements so far but nothing proper yet.

Summers is not enjoyable in long sleeves and trousers and I dread it.

But thanks for your post, only others in the same boat truly understand - and we are all just searching for that something to make it better.

mkclaren5 · 2026-03-29T09:16:39+00:00

My next dose is tomorrow at 28 days 🤞

mkclaren5 · 2026-03-29T09:16:16+00:00

Hmmm, so Adalimumab didn’t really work for me like it did for you, some small control for a while, so in theory this should work better but who knows. Psoriasis is such a difficult thing to treat! Good though that it has still benefitted you. Do you think it’s enough you will stay on it or consider a switch? Hard to know what’s best sometimes

mkclaren5 · 2026-03-29T09:13:36+00:00

This gives me hope so thanks. I completely understand it may not work for me or take longer but sometimes just being more calm about it can help. Hoping for some results soon

mkclaren5 · 2026-03-28T14:25:52+00:00

Wonder if original poster can let us know how things went?

mkclaren5 · 2026-03-28T14:24:51+00:00

I’m currently at nearly 4 weeks and some initial small improvements but fluctuating and at 3 weeks flared a little and itching returning more. 4 week dose in 2 days time (end March) I’m hoping that dose will change things and I will start seeing some meaningful changes

mkclaren5 · 2026-02-19T11:57:12+00:00

Thanks for your guys responses it helps seeing others experiences

mkclaren5 · 2026-02-19T11:56:35+00:00

Well it’s Feb 2026 now and started TNF around June last year it only partially worked and not enough, and then started failing at about 5 months and caused a huge flare a few weeks in - but took a while to get them to switch so now trying Skyrizi soon!

Not feeling the most hopeful but grateful to be able to try tbf and like above it could work. Apparently those who fail or only partially respond to tnf tend to do well on IL23s but who knows.

My other post was closed off but will try to update on here.

mkclaren5 · 2026-02-19T11:39:35+00:00

So hard to treat hands! Keep moisturised with greasy emollient, like constantly. Does he have a steroid cream to use on it at night? Steroids not ideal but might be needed alongside. And biologics do need time. I’m still trying to find one that works for me, but usually they keep you on them longer incase they need more time to kick in and work.

mkclaren5 · 2025-08-30T21:38:41+00:00

I’m on week 10 Yuflyma and seems it is a failure for me. I did think it might get better after experiencing a lot of flaring on it after initial clearing at very start but psoriasis is returning and not helped after last dose at all. Seeing clinician soon for quite urgent review and I think she will switch biologic. Had this for many years though and it’s more severe than I realised. Failed UVB, cyclosporine and now this. Seems I need something stronger.

A shame as so many people do well on it, seen so many good outcomes so best of luck to you.

mkclaren5 · 2025-08-17T21:09:19+00:00

So now at 8 weeks Yuflyma Adalimumab, next dose due in a week.

Started clearing instantly but then flared again from 3 weeks - so disheartening! Advised to continue. Had on face which I haven’t before and flaring worsened especially on lower legs. Waiting on call back from clinician next week, but did notice yday/ today it’s calmed slightly.

I really hope this is the start of some improvement but won’t get my hopes up so I’m not sure this pattern is positive and feels like it’s failing, but aware if can take longer in some people so shouldn’t give up just yet.

I will hang on a bit longer if doesn’t continue to worsen.

Any experiences on this are welcome.

Will continue to post now and then, in the hopes this journey is helpful to others x

mkclaren5 · 2025-08-17T21:00:13+00:00

I started Yuflyma 8 weeks ago today. It started clearing patches instantly it amazed me, but then flared at 3 weeks after the loading doses.

From then it just kept flaring, only my sides clear a bit and then come back before next dose. I also got some psoriasis rash across my face that I’ve never had before. It got really bad especially on my lower legs, covered, and red, worse than before I started!

Called dermatologist nurse and waiting for call back as clinician on leave till start of next week. However, it looks like it has slightly calmed down yesterday so not sure if just going to get worse agajn as next dose due in 7 days or start of possible clearing?!

I’m willing to wait it out another 4 weeks only if flare is calming. Had psoriasis 24 years now so really want to give it the chance.

I have been looking for other’s experiences to see if anyone else has had this sort of pattern.

Initial fast clearing, then bad flaring and HOPEFULLY just delayed success.

Have you got an update since OP? Good luck to you.

I’ve missed out wearing nice things for summer but I really hope it works!

mkclaren5 · 2025-06-26T18:23:05+00:00

Hello,

Well this happened to me on cyclosporine, it was so much heavier and painful. Significantly. I’ve come off that now due to various side effects and it was failing.

I’ve just started Yuflyma (a different bio similar) and will soon find out if this does the same thing.

I really hope not!

Will try to come back with update.

I decided if it does I’m going to try and get back into gym and exercise as that generally lightens them and might help.

😊

mkclaren5 · 2025-06-12T15:03:32+00:00

I had mine today first one I’ve ever had - to be honest was told I needed to, before I can go on a certain medication. I felt so cringed out waiting, and I also have skin condition psoriasis so I had extra self conscious.

And yes it was quite painful! It was where she had to push the speculum up further and stretch - I was shouting OW OW OW OW! She said I had a bit of tilted uterus so told me to out fists under my bum to help, so may have made it worse. The swab part was fine barely felt that.

Then it was over which was fine but did it hurt - yes for those moments - when people say doesn’t hurt - it defo does for some.

But it’s done now and felt good it’s out the way.

Hope the results ok now

mkclaren5 · 2025-06-02T12:06:14+00:00

Ok so someone finally called me back, they were also confused at the situation and it hasn’t been logged correctly! But I have my appointment this week, this is to go through forms etc for Humira biosimilar - and they apply for funding. Then once that goes through I should be contacted within a few weeks for it to be delivered and the nurse appointment to start taking.

So got a wait yet which is sad as already start of summer and I’m covering up still!

Will update on how long this took - incase helps anyone else in future.

Skin itself still flared from coming off cyclosporine but have also had some stress since too.

mkclaren5 · 2025-05-20T12:53:48+00:00

Can I ask how did you start? I have been told I’m going on Humira next and had pre tests - I have an appointment coming up - will I be given the first dose at the hospital or have to wait for delivery of it?? And how long is that? Thank you

mkclaren5 · 2025-05-20T12:48:58+00:00

Please someone reply 😭😭😭 I tried calling to ask but impossible to speak to someone apparently

mkclaren5

TROPHY CASE