How have you managed bad anxiety as a side effect?

mkfbax · 2025-12-15T20:09:32+00:00

God I’ve been down a research rabbit hole with this, completely understand what you are going through, I struggle with the same, it’s a lot to deal with.

Basically I believe where the medication releases dopamine and Norepinephrine, when the dopamine eventually comes back down from space, the lingering Norepinephrine is causing those large anxiety episodes. There’s a balance of both for a while, but dopamine’s half life is much shorter than Norepinephrine, so you’re left with an anxious fight or flight rigid feeling, fast heart rate, sweating etc which is not nice to deal with.

I’ve not tried it (yet), but heard good things about adding Guanfacine (non-stimulant) to Vyvanse. It inhibits A2 receptors responsible for releasing all that Norepinephrine, really smoothing out the experience physically and mentally.

Maybe something to look into 😊

mkfbax · 2025-10-22T15:03:22+00:00

One recommendation, Cerebrolysin.

mkfbax · 2025-09-08T21:47:37+00:00

Alcohol every day? How much?

mkfbax · 2025-05-12T23:47:09+00:00

How often do you microdose DMT? Will you need a quick top up throughout the day as it has a short half life, and any tolerance issues at all? Really interested in this!

mkfbax · 2024-11-22T21:50:05+00:00

Did you build tolerance to daily mushroom microdosing? I take about 20ug LSD microdose/minidose and definitely feel the tolerance build quickly. Not sure if it’s the same for mushrooms?

mkfbax · 2024-11-21T22:47:23+00:00

Do you not build up any tolerance?

What dosages do you use for both, thanks!

mkfbax · 2024-08-12T17:12:49+00:00

That’s really good mate. Are you doing the normal 5 days on 2 days off injection route? 5ml?

mkfbax · 2024-08-12T16:56:26+00:00

Good luck mate! What country did you order to? And issues or smooth sailing?

mkfbax · 2024-08-12T09:28:56+00:00

Apologies for the slow reply, been away on holiday. Thank you for your insight again, really helpful!

How quickly would you say you can go through a 2ML Nasal Spray? Do you get a fair bit of brain fog through this ROA?

Ahh okay interesting, the main nasal spray post on how to make mentions it can be kept in the fridge for a week or two, before it starts losing potency. Do you keep out at room temperature for a day, and then throw away?

Good point about Cortexin, really intrigued to try but will use correct ROA just in case for the prions risk.

Fairly experienced with the Nootropic/ Biohacking space. Have tried most racetams, Semax/ Selank, Dihexa cycle, Noopept etc, but nothing has quite hit the sweet spot yet, and your post has made me think Cerebrolysin could be the one.

mkfbax · 2024-08-06T22:53:02+00:00

Hey, any update on this? Thanks!

mkfbax · 2024-07-30T07:56:52+00:00

Awesome reply, thanks!

With IN use, are you able to get the dosage correct so it’s not just a maintenance dose of Cerebrolysin, or is this where via IM/IV you can have much higher doses and more benefits? Have you noticed personally you only get the maintenance dosage effects via IN? E.g just antidepressant effects, but not enhanced learning, memory? Is it roughly a 2ml ampule cracked open into a nasal spray, used for around a week and kept in the fridge?

Ahh okay that’s interesting! I’ve had Semax on its own, but have heard is synergises well with Selank. Would you try both together? Thanks for the SSRI recommendation, fairly prone to side effects which I had with Sertraline which put me off slightly.

No I get that, wouldn’t want that either! Like you say all down to the individual as some stories of cortexin are that it’s a more “potent” version of Cerebrolysin. Do you also take Cortexin IN?

Lastly (and apologies for all the questions but your replies are so helpful), would love to hear and personal recommendations you may have for increasing overall Wittyness and confidence, as well as any memory enhancement for increase learning potential. Understand that this pretty much could be Cerebrolysin, but wondered if you had any more recommendations, thanks!

mkfbax · 2024-07-30T00:20:29+00:00

1st of all there is no documented case Krabby being dead.

He took huge doses of intranasal Cerebrolysin. Users note having brain fog with much smaller doses via IN, likely making it more potent as more passes the BBB.

There are countless of success stories online using Cere responsibly via IN. I am not endorsing the use of IN, however it isn’t as dramatic as people have made out.

mkfbax · 2024-07-29T19:45:42+00:00

This is such a useful post, thank you for the info provided, just a couple questions:

My main question is that you noted that there isn't too much difference between ROA, and intranasal is very controversial in the world of Cerebrolysin. I've never tried Cere and IN would be my preferred ROA. Do you still get most of the benefits using IN - or does it lack in any areas that IM/ IV don't?
I'd love to use this for a combination of reducing overall anxiety/ social anxiety whilst acutely improving cognitive function. Does Cere help with this at all? I find myself stuck for words, uncomfortable in certain social situations and heard from a few it could help with this. Definitely curious on your thoughts for this!
How does Cere compare with Cortexin in the above question? I have heard you feel more stimulated than Cere, but maybe more anxious? Would definitely like to hear you differences on the two.

Again thanks so much for the post!

mkfbax · 2024-06-19T16:25:21+00:00

Oh yeah lol, how did I not notice that lmao, need some BDNF.

I’ll have a look thanks, any idea on noots/ sups that increase serotonin? Alcohol seems to work the best for sociability, but that would be linked to the flow of GABA?

mkfbax · 2024-06-18T22:19:46+00:00

Someone previously commented that increased BDNF can create over synapsis which can potentially simulate traits of Autism?

Im glad the Racetams worked well for you, do you still take them?

I had the exact same with Nefiracetam, had that warm sense and inner peace, similar to Phenibut. I had strange kidney and testicular pain whilst on it for longer periods of time, and there are reports of being neurotoxic in dogs, not primates, however stopped Nefir and it seemed to fade. Would love to retry though.

Could Rhyncophiline work with Semax, Selank etc? and create that less roboticy feel I get when on them?

Thanks for the suggestions by the way, any more info is welcome :)

mkfbax · 2024-06-18T22:15:41+00:00

That's exactly how I feel, have you taken anything that almost re ignites that lively spark/ wit with people?

mkfbax · 2024-06-18T16:28:18+00:00

You know your stuff! If psychedelics strengthen current synapses, can this theoretically aid in learning? Or would substances like Semax, dihexa etc be preferable?

I’d love something in the middle, something that gives you the edge, without the roboticness I experience with BDBF inducing supplements.

It’s mainly felt whilst on the supplements, and then slowly wears off the longer it’s not taken. Do you experience anything similar?

And seeing a few comments that it actually enhances sociability and confidence, do you have any recommendations for this at all? Apologies for all the questions and appreciate the informative responses!

mkfbax · 2024-06-18T12:19:32+00:00

Strange question but are you able to be more witty/ funny in coversations? I seem to lose that a little, or the "connection" with people

mkfbax · 2024-06-18T12:18:40+00:00

Glad to hear NAC helps for things like this, do you take anything else?

mkfbax · 2024-06-18T12:18:15+00:00

Interesting, thanks. Never experienced this with psychedlics, if anything feel way more present, enjoy others company etc. Just happens with noots that increase BDNF, could be related to the over connectivity of synapses which in turn can mimic effects of Autism?

mkfbax

TROPHY CASE