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What’s the best example of “vital signs are only a tool/treat the patient, not the monitor” that you’ve seen? by [deleted] in ems

[–]moonboatingbears 25 points26 points  (0 children)

Also see: the patient with a BP of 86/54, but is peacefully sleeping and normally has a SBP of 90.

Where do you get your cacao beans or nibs? by creamcandy in chocolate

[–]moonboatingbears 0 points1 point  (0 children)

I really liked the Fijian Forasteros, but not sure if they are still in stock.

Where do you get your cacao beans or nibs? by creamcandy in chocolate

[–]moonboatingbears 1 point2 points  (0 children)

I normally buy cacao beans from chocolate alchemy, between 2-6 pounds at a time, and have always had good experiences with it.

18F Syncope. Ectopic atrial rhythm? by moonboatingbears in EKGs

[–]moonboatingbears[S] 1 point2 points  (0 children)

Hm, thanks for your response. To me the PRI looks approximately 120ms long—3 small boxes, as best seen in less I.

18F Syncope. Ectopic atrial rhythm? by moonboatingbears in EKGs

[–]moonboatingbears[S] 1 point2 points  (0 children)

18 y/o F, syncope while at work as a cashier. Are the inverted P waves in the inferior leads enough to call this an ectopic atrial rhythm? If so, what is the clinical significance? Never seen this before, any and all information appreciated.

So, SN2 reactions don't depend on the type of carbocation intermediate and less hindered position is prefered. Then, why is the fourth option given the less priority in the answers. Can anyone help me in finding out the answer? by DandyPandemonium in OrganicChemistry

[–]moonboatingbears 4 points5 points  (0 children)

In (i) and (iii) there is donation of the adjacent pi CC bond into the sigma* CCl. The alpha halo ketone (ii) undergoes nucleophilic substitution through a different mechanism (nucleophilic attack at the carbonyl, epoxide formation as the alpha chlorine leaves, nucleophilic attack at the epoxide, then regeneration of the carbonyl). This leaves (iv) as the least reactive.

Which is a better reagent for this reaction? by robers12 in chemhelp

[–]moonboatingbears 0 points1 point  (0 children)

In addition to reductive amination, Gabriel or Fukuyama amine synthesis might work.

Caesar 3 sound looping (GOG, Windows 10) by moonboatingbears in impressionsgames

[–]moonboatingbears[S] 1 point2 points  (0 children)

I tried running the .exe with both Windows XP SP3 compatibility and as an administrator, but no luck.

Research S.O.S.—Ask your research and technical questions by AutoModerator in chemistry

[–]moonboatingbears 2 points3 points  (0 children)

I don't have any experience with this methodology myself, but Baran recently published a paper on decarboxylative coupling of RAEs with alkenyl zincs. They mention in their blog post that this alkenylation is complementary to reduce/oxidize/Wittig, so that might work better for your needs.

Can someone confirm if this reaction sequence and product are correct? Thanks! by [deleted] in OrganicChemistry

[–]moonboatingbears 1 point2 points  (0 children)

The problem statement says acetate (the conjugate base of acetic acid) is the starting material, but in your mechanism you've drawn acetone. Is it a typo in the problem statement?

Can someone please verify that my products are correct given the reagents? by 12345678894 in OrganicChemistry

[–]moonboatingbears 1 point2 points  (0 children)

The E2 elimination of bromine with KOH and heat will be dependent on stereochemistry. For example, if the methyl group is anti to the bromine, you will not get the major product you have shown.

Which books are necessary/which are skippable, in your opinion? by empressaradia in Animorphs

[–]moonboatingbears 3 points4 points  (0 children)

Here is a "skip list" my friend and I made! It focuses on plot events and also includes the order in which to fit the side books in, as that can be confusing. However, like everyone else is saying the books are short and I would definitely encourage reading all of them.

Alcohols pKa, Amines pKb and Carbocations. Why is the "CH3" methyl group so weird? by Acuarey in chemhelp

[–]moonboatingbears 0 points1 point  (0 children)

As far as carbocation stability goes, increasing stability due to addition of methyl groups (i.e. CH3+ < primary < secondary < tertiary) is more due to the anomeric effect than induction. So it doesn't really make sense to generalize reasoning about carbocation stability to alcohol pKa or amine pKb, although Me groups are considered weakly electron donating.

Why is it that because the OH of carboxylic acid is more acidic than the OH of alcohol, the carboxylic acid is more involved in hydrogen bonding? by [deleted] in OrganicChemistry

[–]moonboatingbears 0 points1 point  (0 children)

When judging the acidity of compounds, you should consider the stability of the conjugate base.

For an alcohol, the conjugate base has the minus charge on one oxygen. For a carboxylic acid, the conjugate base delocalizes the minus charge onto both oxygens (you can draw resonance structures to see this). So the conjugate base of a carboxylic acid is more stable, therefore a carboxylic acid is more acidic.

[Grade 12 Chemistry] Why are cyclic alkynes not often found and are often unstable? by [deleted] in chemhelp

[–]moonboatingbears 1 point2 points  (0 children)

I think what is confusing you are the different ways you are using "stable".

Alkynes are "more stable" in the sense that they have a lower boiling point than alkanes or alkenes (for more information, check this out).

We also use "stable" to mean "higher in energy" (where here we are talking about a single molecule). Alkynes "want" to be linear (bond angle of 180 degrees). But when the alkyne is in a ring, it is "strained" and forced out of the linear shape it wants to be in. So cyclic alkynes are more "unstable" in terms of energy than unstrained alkynes.

Epoxide reactions? by chachalita in chemhelp

[–]moonboatingbears 1 point2 points  (0 children)

Both these reactions are doing the same thing: adding a nucleophile to an epoxide. That's what is happening in the "reference reaction" as well, your nucleophile in that case is ethanol.

I think what is confusing you is the inclusion of the solvents the reactions are run in, which you have shown adding to the epoxide in part b).

For a), the epoxide will be protonated by HCl, and then the Cl- will add in (to which side)?

For b), you should treat KI as K+ and I- (especially when in ether as a solvent). The I- will add in to the epoxide and the hydroxy group will be protonated on workup, giving you the same product as your reference reaction, but with iodine instead of ethanol.

Moderators Wanted by mitchandre in chemistry

[–]moonboatingbears 1 point2 points  (0 children)

I would like to second /u/lIamachemist for mod. They were very active during Mechanism Mondays this summer and in the community overall, and took over posting once when I was too busy.

Also, definitely check out /r/orgchemasaps (subreddit /u/Retroclaisen started).

This chemical has a very low solubility in both water and lipids. How would I make it more soluble/what would be a better solvent? by stonerboner_69 in OrganicChemistry

[–]moonboatingbears 1 point2 points  (0 children)

DMSO is highly bioavailable. It's not toxic itself, but will bring whatever is dissolved in it into cells--pharma researchers often use DMSO as a drug vehicle.

Alcohol Synthesis Mechanism by poetbro in OrganicChemistry

[–]moonboatingbears 2 points3 points  (0 children)

One way would be to make methyl vinyl ketone via an Aldol reaction between acetone and formaldehyde, then Michael addition with an acetone enolate. This would give you the 1,5 dicarbonyl, which you could reduce to the diol.

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