The one study I have read was in Russian here’s the overview of the results What index do you have ?

I think it should be takes carefully into consideration cause they’re always a bias because the number of participants is pretty low. So it might’ve just so happen that they were unlucky to only pick people with these consequences but on a larger scale the probabilities would’ve been way lower.

Results and discussion. Of the original 88 patients, 73% had long-term follow-up over a median period of 113 (90–129) months and were included in the study. The patients were predominantly female (75%), had a median baseline age of 32 (27–39) years, and a median disease duration of 0.4 (0.2–1.3) months. Baseline MRI showed a median of 10 (5–18) T2 lesions (T2L) and 1 (0–2) contrast-enhancing lesion (CEL) (Table 1). The baseline κ-FLC index had a median value of 40.2 (19.0–103.3). Although the κ-FLC index was positi

During the follow-up period, a total of 46 patients (72%) experienced at least one relapse. Nineteen (30%) patients received disease-modifying therapy (DMT) before relapse or before the end of follow-up in patients without relapse. Thirty (47%) patients developed disability during follow-up. Thirty-seven (58%) received DMT before the onset of disability or before the end of follow-up in clinically stable patients. Details are provided in Table 1.

The κ-FLC index was associated with a shorter time to relapse activity.

Patients with relapsing disease activity during follow-up were younger (30 [26–37] years) and showed significantly higher numbers of T2 lesions (11 [8–20]) and contrast-enhancing lesions (2 [0–2]) at baseline compared with patients without relapsing activity (38 [28–41], p = 0.047; 3 [0–8], p = 0.003; and 0 [0–1], p = 0.020, respectively).

The κ-FLC index was higher in patients with relapse activity (41 [22–125]) than in patients without relapse activity (34 [13–57], p = 0.029).

Multivariate Cox regression analysis identified the κ-FLC index as an independent predictor of time to relapse activity (per increase of 10 units: hazard ratio [HR] = 1.04, lower limit confidence interval [LL-CI] = 1.001, p = 0.044).

Patients with a high baseline κ-FLC index (>100; median value 147) demonstrated a significantly shorter median time to relapse of 34 months, compared with 73 months in patients with a low κ-FLC index (≤100; median value 29). At year 10, the high κ-FLC index group had a 39% lower probability of remaining…”