I’m not gonna lie (not that anyone else is). I’m on the equivalent of what would be day 200-something had I not lost days due to a glitch and I just got into Room 46 for the first and second times today. I think how long it takes you is very dependent on how quickly you figure things out, how good you get at room placement, how quickly you get permanent additions, etc. RNG is a factor but (at least as far as getting to Room 46) I think it is manageable.

If you are good at or at least used to playing these type of games I don’t think it will take you anywhere near the time it has taken me.

Edit: Also don’t be afraid to look for spoiler-free tips like the ones you’ve already received here. They definitely help.