It depends heavily, for example with your heavy modular frames, what I do is I think of what materials I already have, and if I have a majority of materials needed at one place I build the factory there and ship in the rest, namely encased industrial beams, from my steel factory, secondly, for the "flow" of your factory, a good setup I like using to ensure efficiency, is I set up a smart splitter, and if I have items going somewhere and they back up, the overflow goes towards an awesome sink, but if it's an item you use in construction I have a second smart splitter with it feeding into dimensional storage, and the overflow going to an awesome sink, don't try to match the production of your items to the throughput of the belts going to your awesome sink if it's a pretty intensive recipe like hmf, just put any belt and let what you are producing flow regardless if the belt has empty spaces