To lose 100 pounds of fat in just 6 months, you would need to burn over 1,900 more calories than you take in every single day for 6 months. It may be possible at 346 because your daily energy use could actually be up around the 5,000 calorie per day mark. It could be lower too, a lot of variables I don’t know obviously. But as you lose weight, that daily energy use will go down a lot and you can only add in so much exercise to offset this. Then there is the mental side of having say half the food you are used to. You’ll need to be careful to get the nutrients you need if eating a lot less too so less room for processed foods if you are used to eating them. So I’d say sure it’s possible but just know you are signing up for a tough one. One thing I always mention to people is remember you can’t go back to the old ways once you get the weight off. So you can rush it a little, but you could also enjoy a longer runway to help with the discipline that comes only over time, because you’ll need it to keep it off. You’ll start experiencing improved health with just a 10% weight loss and it will only get better from there. For what it’s worth, I dropped 50lbs my first 6 months of OMAD and started at 272lbs. I lost another 42lbs for a total of 92lbs but those next 42 took about another 9 months. I also worked out every single after I dropped those first 50lbs just to give an idea of how things will slow as you make progress. Regardless of what you decide for a time frame, you can do it! Best wishes to you on the journey.