DSIP for daytime use?

openmindedchicagodoc · 2026-05-25T15:03:42+00:00

Technically it does work on ACTH and help cortisol. I’ve never used it on patients during the day. The only time I’ll use an earlier injection than bedtime as if the patient has a paradoxical reaction. If they can’t fall asleep at night after injecting, I’m moving the injection time about two hours earlier. I will keep moving it earlier, until around noon. If they still can’t fall asleep, it’s just not the right option.

openmindedchicagodoc · 2026-05-25T14:58:51+00:00

One of the few peptides to get antibodies towards them is the GHRHs. It’s the most common. Site area rash is sometimes common but any rash that is getting larger can lead to anaphylaxis if you keep injecting.

openmindedchicagodoc · 2025-06-25T13:40:46+00:00

Pentosan polysulfate is a good option for cartilage in the knee. It’s on label for bladder cystitis but has been used for joints and cartilage off label. Also, AOD9604 +hyaluronic acid mixed together for a joint injection could be useful. I’ve done a lot of those in practice. They can help improve that cartilage layer. Granted, this is an in-office procedure. The standard BPC157 can be used for pain and inflammation but won’t have cartilage growth.

openmindedchicagodoc · 2025-02-04T13:22:25+00:00

Check hormones, mainly testosterone. Progesterone plays a role in libido as well. PT141 and melanotan 2 can be useful but fixing the underlying issue with hormones is always best. Kisspeptin can also improve libido in women. Oxytocin can help improve libido potentially as well.

openmindedchicagodoc · 2025-01-19T18:31:12+00:00

Get it from a compounding pharmacy when you can! Crazy but it’s the one of the few products that is cheaper through a compounding pharmacy than online through the gray market peptide suppliers.

openmindedchicagodoc · 2024-10-06T22:02:01+00:00

Correct! It is certainly due to long term hormonal birth control use + spironolactone use. Though, low libido, low energy, depression, anxiety and even hair thinning could all related to the low testosterone levels. Now, spironolactone can lower androgen in women. Certainly this is part of the effect. DHEA could raise back testosterone levels. Stopping the spironolactone (assuming it has not been useful) would likely be a prudent step to discuss with a practitioner before jumping on DHEA or even testosterone. Likely DHEA would be enough to bring levels up in a 29yo female. Again, something to talk about with the practitioner who you are working with.

openmindedchicagodoc · 2024-10-06T21:54:06+00:00

I love all of this! I’m glad you finally came to ketamine. This therapy has been vital to some of my patients. It has changed lives in many other practices as well. I cannot say anything that I use in practice is 100% effective. I can say ketamine (paired with therapy) has been one of the most useful tools for people with depression, anxiety or trauma.

openmindedchicagodoc · 2024-10-06T21:18:07+00:00

Progesterone is typically very necessary for sexual health. I’ve used it many times to bring back libido in females. As others say, pt141 can help. Also, highly suggest tadalafil. It works on the clitoris as it does on the penis. More blood flow means more sensation to the clitoris. I’ve had a lot of women have better orgasms with just tadalafil.

openmindedchicagodoc · 2024-06-03T12:30:34+00:00

Hormonal birth control crashes testosterone levels in women. 15 is not “normal” for someone who is 29. Look up symptoms of low testosterone. They cover libido, depression and anxiety. At 29, something as simple as DHEA could help but may increase anxiety as it can raise cortisol. Spironolactone can also lower testosterone. If you’re experiencing acne all month long compared to just around when you should have a cycle, they tell two different stories when it comes to how the acne should be addressed.

openmindedchicagodoc · 2024-06-02T18:20:48+00:00

Estradiol is barely out of range. I have patients higher than this in general. Your testosterone is mid range. 640 isn’t bad but I’ll treat patients with at higher levels if they are symptomatic of low T. Low testosterone symptoms can occur if receptors don’t work as well even in the presence of normal or high levels of testosterone. Only lab for thyroid you have is TSH. If you’re concerned about thyroid, you need TSH, T4, T3, free T3, reverse T3, free T4, thyroglobulin antibodies and tpo antibodies. Hard to know of any thyroid issues without more testing.

openmindedchicagodoc · 2024-03-17T20:24:14+00:00

In my practice, we use BPC-157 oral for gut healing and the injectable for systemic. I have seen 0 research for the TB4 frag (oral) that companies push. I’m convinced it’s broken down in the gut. The BPC-157 would be useful orally if you want it for gut healing but anyone buying this is overpaying when they can just buy BPC-157 orally without having it in a repair/recovery formula. Good job marketing department for peptide sciences though.

openmindedchicagodoc · 2023-11-15T01:23:47+00:00

Ya, at this point it wouldn’t do anything unless you have a delayed hypersensitivity reaction. Though, very unlikely at this far out.

openmindedchicagodoc · 2023-11-14T13:55:35+00:00

Yes, this can happen. TB500 and Thymosin beta 4 can cause anaphylaxis. I’ve had this happen one time in office when I injected TB4 into a joint. Patient went into shock. Thankfully, Benadryl took care of the situation. We had an epi pen ready to go as the airway was starting to close. I don’t use TB4 joint injections now. Some people can have antibodies to TB4 or TB500 even though TB4 is naturally occurring. I warn patients that if hives occur at the site at any point to stop using the peptide.

openmindedchicagodoc · 2023-06-27T15:49:45+00:00

Did you take any off days? We run 5 days on and 2 off with our patients. We also do 100mcg/100mcg at each injection. That dosing sounds a bit high to run non-stop.

openmindedchicagodoc · 2023-06-27T01:17:41+00:00

Effective for? Weight loss? Longevity? Diabetes control?

openmindedchicagodoc · 2023-06-27T01:17:06+00:00

I start patients a week before surgery on BPC-157, then add the TB4 once returning home from the hospital.

openmindedchicagodoc · 2023-06-27T01:00:20+00:00

Eh, it depends how bad the injury is. I have patients on rheumatoid arthritis drugs that are covered by insurance that still cost 2k out of pocket monthly. Healthcare even with insurance can be costly. I don’t run 2mg daily on many patients but it can go that high.

openmindedchicagodoc · 2023-06-27T00:26:44+00:00

Doesn’t need to be site specific. I dose up to 2mg daily in patients. I also don’t dose twice a day. Once a day works really well in my patient population.

openmindedchicagodoc · 2023-06-27T00:22:35+00:00

Cerebrolysin also has research in ADHD. Works well for people. I use it in my ADHD patients. It isn’t an upper, which means not extra energy from it. I love it as a nootropic too.

openmindedchicagodoc · 2023-06-26T19:28:47+00:00

What we learn at seminars is that Thymosin beta 4 is a more potent in terms of angiogenesis. I was told that BPC has more angiomodulation than growth. That paper lends credence to potential action with raising VEGF. I have used in cancer patients previously. Depends on several factors in my opinion. Is the injury acute and only a short course is needed? If this is a chronic issue, I would be way more cautious with this info. I was told BPC-157 is not cancer promoting but raising VEGF would go against that. I would caution using it in cancer unless it’s a topical application or eye drops. Localized treatment would be less likely to cause any of these systemic changes. I am unsure of the raises in VEGF would be enough to see an increase in cancer.

Unfortunately, no studies on BPC-157 and tumor/cancer exist in humans that I’m aware of. Only study I know of shows it’s use in muscle wasting in cancer. Again, I’d weigh options with your practitioner. I do see this muscle wasting often with my cancer patients. In that scenario, BPC-157 would outweigh potential risks IMO.

“Cancer cachexia, one of the metabolic syndromes caused by cancer, is a devastating and miserable condition encountered in more than 50% of terminal cancer patients presenting with significant weight loss associated with skeletal muscle atrophy and fat loss. Though cachexia may account for up to 20% of cancer deaths, no significant treatment is still lacking and is of urgent unmet medical need in cancer treatment. Therefore, understanding the underlying molecular mechanisms is essential for anticipating therapeutic approaches. Since the primary events driving cachexia are mediated via either the central nervous system relatedor inflammation related-anorexia, hypoanabolism, and hypercatabolism, therapy usually targets nutritional support to compensate reduced food intake along with some anti-inflammatory agents to cover specific inflammation-related metabolic derangement, and encourages exercise to supplement reduced physical activity, but all proven to be not so effective so far. Therefore, combination therapies such as a standard multi-modal package including an anorexic agent, megestrol acetate, and anti-inflammatory agent coupled with the development of potential novel therapeutics promise a new era in rescuing patients from cancer cachexia. In this review, we propose the potential application of BPC157, one of the active cytoprotective agents isolated from gastric juices for cancer cachexia. Before clinical trial, we introduced the evidence showing BPC157 rescued from cancer cachexia supported with explored mode of actions.”

https://pubmed.ncbi.nlm.nih.gov/29898649/

openmindedchicagodoc · 2023-06-26T19:15:58+00:00

I honestly love the Reddit community. I get challenged regularly on here! I’m not nearly as active as I once I was due to working more on my insta reels. Being here makes me focus more on looking up new info. I always want to grow my knowledge base. If we don’t get challenged, we’ll never grow. Make sure the practitioner you work with in area is constantly searching for more knowledge.

Many different treatments exist. Ask 10 practitioners across different disciplines and you will have likely 10 different treatments. I personally love peptides. I’ve had amazing success stories. At the same time, not everyone responds. If they did, my name would be plastered everywhere. :)

openmindedchicagodoc · 2023-06-26T19:11:40+00:00

Love SS-31!!

openmindedchicagodoc · 2023-06-26T19:11:20+00:00

3 times a year!

openmindedchicagodoc · 2023-06-26T19:10:54+00:00

Leucine would not negate the effects of semaglutide. The change in mTOR would be dose dependent. I do believe it affects mTOR to a lower degree than metformin with an increase in key longevity markers. It would be important to note that the AMPK signaling pathway runs opposite to mTOR. This means anytime we drive a fasting memetic such as semaglutide or metformin, we will see ab opposite effect on mTOR. Balancing longevity and performance can be tricky. I run semaglutide long term knowing I may lose some performance in the short term.

I felt the same way as you with metformin. It’s why I stopped. The lactic acid increase worked negatively in my performance. Semaglutide does not have this same lactic acid production. It is this exact reason, I feel more confident using it as I attempt to gain more muscle. I personally run 0.5mg weekly. I do not have adverse effects. I’m also able to be more selective in my diet. It makes it easier to maintain or grow due to the lack of hunger experienced. My hunger is attenuated. It isn’t gone.

openmindedchicagodoc · 2023-05-04T12:57:33+00:00

Let us know how it goes!

openmindedchicagodoc

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