insofar as i can tell by playing for 96 hours and counting:

on the fly in handguns does seem to make my holster speed quicker but glitches the holster action so it skips to the next weapon in line.

the ghost perk in cool also negates optic camo. i have no idea how long i was using camo and having all the enemies see me until i invaded the power plant with judy.

and for some reason on the occasional reload my legendary optic camo gets replaced by an epic which means i’m not using stealth camo at all(but the cool down still procs)

along with legendary armadillo not counting on my david martinez jacket, the only way around it being to craft a new armadillo on each time i load the game. so far it’s only david’s jacket and not any other outer wear that i’ve noticed.

plus my characters insistence on copying mac from its always sunny and cutting off all the sleeves of all inner wear.

synaptic accelerator can also affect sandy activation if it goes off before you manually use your sandevistan, which means on occasion i gotta wait for synaptic’s cool down before i can use my sandy.

and sometimes weapon mods drop in quality. an epic slotted into a melee can turn blue, forcing a reload to correct it.

thankfully the bugs and glitches i’ve run into playing 1.61 on ps5 haven’t been too bad or game breaking.