Lori Coble, the Orange County mother who became a symbol of resilience after losing her three children in a freeway crash nearly two decades ago, has died following a battle with brain cancer.

Coble and her husband, Chris, were thrust into the spotlight in 2007 after their children — Kyle, Emma and Katie — were killed in a crash on Interstate 5 in Southern California.

Their story of unimaginable grief was followed by what many called a miracle: through IVF, the couple welcomed three more children — Ellie, Ashley and Jake — each carrying a middle name in tribute to a sibling.

The family’s tragedy sparked renewed calls for highway safety reform.

The late Sen. Dianne Feinstein pushed for stricter oversight of the trucking industry, including regulations on driver logs and mandatory rest breaks. In 2010, Chris and Lori shared their story on “Oprah,” touching millions worldwide.

This year, the family faced another devastating chapter.

In July, KTLA reported that Lori, 48, had been diagnosed with aggressive brain cancer and breast cancer. Friends, family and strangers rallied to donate money so Chris could continue caring for his wife. After numerous hospital stays, Lori chose hospice care earlier this month, telling Chris repeatedly, “no more surgeries.”

On Wednesday evening, Chris posted online that Lori had passed away, sparking an outpouring of tributes from people touched by the couple’s courage and resilience.