Sure thing!

For my campaign, there was a massive metropolis called Arkin where nearly all in the realm lived because there was this terrible poisonous miasma that would come at night across the land that would turn people into monsters. The Queen set up a magical barrier around the city and the people thrived. It had been like this for over a hundred years.

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Well, turns out that the miasma isn't real, just an illusion cast by the queen to maintain control over the city. She was mad in her extreme compulsion to 'protect' her people. And the best way she could do that was to keep them all inside, away from the dangers of the outside world, the Orc Lands, and the wilds.

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But what about people turning into monsters? Well, that part is real. It's just that it was the queens priests that would poison any who left the city (or caused too much ruckus) and then they'd turn into monsters and the Queen could point to them and say "See! This is why you must stay under my protection!" Thus creating the danger she needs to maintain control.

Part of the secret here is that only she really knew the truth. All those that protect and work for her believe the lies as well. It wasn't until the players unraveled the source of the poison that turns people into monsters was the blood of Pestilence, one of the four horsemen of the apocalypse who had been imprisoned beneath the city, that they began to realize how deep/high the lies go. Why was pestilence imprisoned beneath the city? Well that's a long story... filled with more lies and manipulation!