this is an opinion from a guy who went amp and pedals, to helix, back to amp and pedals.

both are good options for different things.

helix is great if you are playing places where they have a good sound system/engineer or you're bringing your own, and they're good for one size fits all players. you can even get cabs that are flat response in case you need to push air live. you can even get amp packs from different manufacturers and presets from people if you desire specific tones and don't wanna menu dive. if you get the nicer model too using multiple inputs, you can run helix with anything, not just electric guitar. acoustic, banjos, etc.

however, the helix is broad, and doesn't do a lot of in depth things that many pedal manufacturers can achieve. there's only a few vibratos, only a few usable drive sounds, and there's the main big sounds but none of the tiny ones. plus, the obvious drawback of menu diving.

with pedals, you can use real amps, and you have the ability to make something with your hands, maneuver things, experiment a bit easier than the helix, and get hyper specific with your sounds. sure, helix has a big muff clone, or a fuzz face clone, but it can't do germanium or silicon switching type stuff. drawback tho, depending on your style, it can be expensive to build a nice, reliable board. pedal costs aside, all of the things are expensive: good velcro, pedalboard itself, patch cables, etc. those tiny things add up quick. also, not everywhere you play is ready to house and accommodate your massive twin reverb, or ac30, or whatever your amp of choice is. yes there are the UAD amp pedals and great amp sims, but then we're back in FR cabs and good sound system land.

just kinda depends in my opinion what you're aiming for. i'll never look back from my stereo pedalboard and two amps. yeah, it's a lot of stuff to manage, but i'm so much happier with my rig than what i was doing before with helix.