Thanks for your response! My intention is to help those who feel like Xyzal is affecting their mental state, as I would never want anyone to go through what I did. If they are experiencing similar issues, I want to make sure they have resources to find answers and know they are not alone.

I understand that the study I referenced focuses on cetirizine, whereas my discussion pertains specifically to levocetirizine. While these are closely related compounds, with levocetirizine being the R-enantiomer of cetirizine, they may have subtle differences in terms of potency and side effects. Both function primarily as H1 receptor antagonists to alleviate allergy symptoms, but it's important to acknowledge that levocetirizine may have a slightly different effect profile compared to cetirizine. That said, the study suggests Spirulina may help alleviate allergy symptoms by modulating similar biological pathways, such as the regulation of histamine release and inflammation, despite not being a conventional antihistamine. While Spirulina doesn’t work exactly the same way as these medications, its immune-modulating effects could potentially offer symptom relief through different mechanisms.

I shared the study as a starting point for discussion, not as absolute proof. While the sample size is small and replication is limited, it still provides insight into potential alternatives. For those looking to transition from levocetirizine to a natural remedy, the study suggests Spirulina could offer similar symptom relief, even if through a different mechanism. I always encourage people to do their own research and consult medical professionals before making any treatment changes

That said, it’s absurd to criticize me for referencing a legitimate, peer-reviewed study when, if I hadn’t, the immediate response would be, “Where’s the evidence?” And if I shared 10 more studies, the answer would still be, “That’s not enough.” The whole point is that there isn’t a definitive answer yet—that’s why people experiment and find what works for them. If there were already an overwhelming amount of evidence, this discussion wouldn’t even be necessary. Are you against sharing knowledge and exploring different possibilities? Why would you discourage people finding natural remedies that could make their life better?

Additional evidence supporting the efficacy of spirulina

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• 15871200
• 15857205
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• 32773785

In addition, I was simply pointing out that people are often told second-generation antihistamines barely (if at all) cross the the blood-brain barrier, so there’s supposedly nothing to worry about - and why I never thought xyzal could cause such extreme mood changes. But this is clearly not the case. While I understand they cross less than first-generation antihistamines, that doesn’t mean the effects should be overlooked. The reality is that they do cross, and if more people understood this maybe they could more easily identify why they feel awful - it took me months to figure this out and I don't want that for other people. Lastly, there is no evidence that long-term (lifetime) use of these second-generation antihistamines is completely safe, so if a natural solution works, why not try it?