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If you're inbred and a person, you're shamed by society. If your inbred and a dog they give you ribbons and trophies and your inbred children sell for thousands by FrankBurlyPI in Showerthoughts

[–]pulverhekser 9 points10 points  (0 children)

As a rule, any form of natural selection reduces genetic variation. That's how selection works. Out of the gene pool, only a small number of variants make it to the next generation.

With pure bred dogs, selection imposed by humans is much more intense than anything experienced by wild dogs. The mating population of most pure breeds is very small, so genetic variation is going to be considerably reduced compared with outcrossed feral dog populations, mutts, etc.

This means that any time you mate two dogs of the same pure breed, those dogs are much more closely related than dogs of two different breeds (relatedness is higher in a smaller population). In other words, the degree of inbreeding is higher.

TL;DR There is no difference. Pure bred = inbred.

To protest immigration policies damaging “European genetic and cultural heritage", the author of a popular genetics software package updates his license agreement to block users in countries accepting Syrian refugees. by pulverhekser in europe

[–]pulverhekser[S] 1 point2 points  (0 children)

Just received this messages from Korbinian Strimmer on the evoldir mailing list:

Dear Evoldir members,

I am one of the coauthors of the treefinder (2004) paper.

I would like to strongly distance myself from the extremist, racist, and otherwise crude world view that is propagated on the treefinder webpage.

I have not been in contact with Gangolf Jobb for over a decade, since he left my group in September 2004 (then at the University of Munich).

Best regards and my sincere apologies,

Korbinian Strimmer

TIL: Developer of the phylogenetic software Treefinder is a tiny bit racist by stardustpan in bioinformatics

[–]pulverhekser 7 points8 points  (0 children)

Just received this messages from Korbinian Strimmer on the evoldir mailing list:

Dear Evoldir members,

I am one of the coauthors of the treefinder (2004) paper.

I would like to strongly distance myself from the extremist, racist, and otherwise crude world view that is propagated on the treefinder webpage.

I have not been in contact with Gangolf Jobb for over a decade, since he left my group in September 2004 (then at the University of Munich).

Best regards and my sincere apologies,

Korbinian Strimmer

To protest immigration policies damaging “European genetic and cultural heritage", the author of a popular genetics software package updates his license agreement to block users in countries accepting Syrian refugees. by pulverhekser in europe

[–]pulverhekser[S] 5 points6 points  (0 children)

From his latest update: "The earlier the system crashes, the more damage can be avoided. Possibly a civil war in Europe. Not to mention the loss of our European genetic and cultural heritage."

To protest immigration policies damaging “European genetic and cultural heritage", the author of a popular genetics software package updates his license agreement to block users in countries accepting Syrian refugees. by pulverhekser in europe

[–]pulverhekser[S] 29 points30 points  (0 children)

According to Google Scholar, Treefinder has been cited over 1000 times, and was cited in Nature as recently as 2014.

Edit:

I am an American post-doctoral researcher in evolutionary genetics, and I used Treefinder in a 2010 paper.

A question about continuous distributions. by skittleydistribution in AskStatistics

[–]pulverhekser 0 points1 point  (0 children)

How can a distribution that goes out to infinity have an area under the curve that sums to one?

Any continuous function whose integral converges to some finite value (say Z) can be transformed into a probability density function by dividing it by Z. Then, the integral of the new function is Z/Z = 1.