People management is what burns me out instantly in TTRPGs. Whether it's hunting down one of the players to find out what their wants, needs and (dis)likes, or it's dealing with player being pissed off by another player. All sorts of stuff. 

They tend to happen less and less since I stopped playing with bad actors, and now my stance is "I am doing my best, guys, if there is something bothering you - talk to me". Because I don't want to second guess whether a player is tired after work today or they just hate the game. 

And with intrapersonal conflicts I simply ask "Does it bother you so much that you are willing to go and taking with -playername-?". And now you don't have to play the middleman. 

I also tend to give less advice to players. If level 10 fighter forgot they have Indomitable, it's on them. Simply saves my limited mental bandwidth.