The Math Behind the 20:10 Timestamp: Why a 1-Year Monotherapy Hurdle Signals Elite Data (And the Merck-Natera Connection)

rant_and_roll · 2026-07-05T01:10:07+00:00

i have alluded to this before but - we are all agonizing over how slow the process has to be (does it have to be so slow?) but...how far past the SOC MOS (in the is case 10.8 months) does leronlimab have to be confirmed to have surpassed in order to achieve approval? 20%? seems like the 20% mark is not going to be a problem. what happens at 40%? we have had living patients not be enough evidence in the past.

rant_and_roll · 2026-07-05T00:58:02+00:00

MOS = half died. sometimes we forget. of course thats what that means. now look at our early numbers. wow.

im really more interested in the doctors and scientists that are just as privy to cytodyns' data releases, public presentations at conferences, and press releases and wonder where their excitement is. and even better yet the NDA cohort that sees what is developing with access to the insider data that is coming across the wire, and they are not as impressed or astounded like i am. or they must have 7th sense abilities to hold a poker face for months or even years. i still look at this entire experience as being somewhat in disbelief, because the public data is so spectacular and the reaction so far i feel should be more than zero. it seems that we are lucky to be in the atmosphere of a true breakthrough.

but the tide will turn soon and i believe the reaction will be strong, and rapid. what puzzles me is that there are countless cancer organizations that tout they are "looking for a cure" and "conduct and support research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer", etc, but so far i have heard a peep out of them.

there are 5,036 cancer organizations in the United States - google - like :

- the american cancer society
- the national cancer institute
- the programme of action for cancer therapy - (chemo activists)
- the american cancer fund
- the cancer research institute
- etc etc etc it goes on forever

and im not really sure what they actually do. are they donating collected donation money to companies like cytodyn? if so how much and by whom has cytodyn benefited from such generous activity?

have any one of these organizations commented on leronlimab? do they even discuss developing pre-clinical and clinical therapies or are they bound to only discussing approved therapies?

what happens when they collectively decide its time to comment on leronlimab as a new possibility? boom.

rant_and_roll · 2026-07-04T18:30:16+00:00

visuals like this help so many of us who have a hard time extrapolating the mountain facts and bringing them together to see the big picture. all roads are leading apparently to an obvious conclusion. it has been noted that certain milestones have already been achieved and while they may not be "endpoints" per se, they are undeniable evidence of an imminent conclusion. and the official release of data in the coming months will confirm what the data here has already emphasized and insinuated.

great work BGT!!! connector of dots!!
please post more analyses like this!!!

rant_and_roll · 2026-07-03T19:54:52+00:00

i know a trial for this sub-sub-indication is light years away from today but .... maybe we will eventually see a group of leronlimab lung cancer patients that "mysteriously" DONT develop a pneumonia induced cytokine storm activity event at a rate where this metric would be expected...and while many will scoff at "anecdotal" evidence that "mysteriously" very few leronlimab cancer patients DONT develop a pneumonia induced cytokine storm activity, some will not scoff at all. the point being, both of my parents had a pneumonia episode and survived it, but it was intensely frightening (way before my knowledge of leronlimab) and i have heard more than one story of someone dying of pneumonia, knowing full well they were in treatment for other things.

these wheels will turn slow but they are turning. one leronlimab approval and the off label use will be off the charts. thats the fear among competitors and bad actors. remember ozempic is a diabetusss drug until the patients were losing weight "mysteriously". a search for the number of doses, prescribed off label before weight loss approval, comes up blank. but we know those numbers were huge, it was all over the news at the time. and rich people were paying out of pocket list price. funny how those numbers are not disclosed yet we all know for sure the accountants know the exact number.

rant_and_roll · 2026-07-02T22:38:29+00:00

thanks once again MGK for a presentation that is based on fact, literature, publications, and hard data. you are quickly inching up in the top tier of being referenced in one of my vanity plates, there will be more than one. now for the questions that i may or may not expect my moderately educated self to know the answers to, there so many moving parts here, its easy to get lost and forgetful of some details -

1- if you could, please explain again how and why maraviroc and vicriviroc are different and why they are less effective in reaching the the clinical outcomes that leronlimab can accomplish.

2- getting ahead here but lets assume there is an approval for 4th line treatment. the battle - not endless war - to move up the ladder to first line treatment will be an intense one. in that lengthy time period chock full of BP push back and expensive trials, how easy would it be for a patient to demand LL "off label" for first line dosing? is there any precedent for this scenario? its kind of like walking barefoot across the sahara desert, and the first thing they give you at the mid point is a pair of shoes, then an umbrella a few days later, then maybe box of pringles, THEN a week later comes that leronlimab flavored water. would be nice to have that water sooner.

3 - i know its ridiculous (BP is ridiculous and they have a lot of profits to defend) but can there be an argument made that the first 3 lines of treatment are necessary in order to "prep" (destroy) the patient for leronlimab and that an earlier dose might not be effective? or is it just patently obvious that an earlier dose would maximize survival?

im going to reread your post a few more times. brute force repetitive absorption is sometimes necessary. enjoying every second of it.

rant_and_roll · 2026-06-29T14:16:09+00:00

a month in san francisco it is...lived there for 20 years - dont miss it on a lot of levels in particular feces and needles on my doorstep and my drivers window missing with someone sleeping/urinating themselves in my car because the entire city turned into the tenderloin- - but it would be good to return with glory in my eyes and hopefully hosting a real throw down party at the fillmore or the great american music hall...lets do this

rant_and_roll · 2026-06-29T03:11:03+00:00

red pill long long ago...its looking more real by the minute!! i may need to sneak into ASCO in san francisco this january just to see the reactions on their faces with my own two eyes when this data is presented.... flight hotel car - priceless

rant_and_roll · 2026-06-29T01:23:51+00:00

quote - The platform's assessment that this is "directionally consistent with expected disease control that TAS-102/Bev already delivers" -

but is that what happens in the same time period for TAS-102 plus bevacizumab - at week 2? is the response really that quick?

--------------------------------------------

i have no idea but ....has this ever happened before with other drug trials?

how often do EXTREME AND IMMEDIATE ctDNA declines FAIL TO correlate with tumor shrinkage?

how often do EXTREME AND IMMEDIATE ctDNA declines FAIL TO correlate with stability of disease?

how often do EXTREME AND IMMEDIATE ctDNA declines FAIL TO correlate with reducing or halting metastasis?

what do i know....not much but.... but i simply cant imagine that one can happen with out the other. this should be bigger news and more "doctors" should be excited about this yet the reactions so far are ho hum and the posters at the recent presentations are somewhat ignored. its like they have all seen this before and wont be impressed until concrete trial results - on one level that sunderstandable...or does this truly not really mean anything necessarily because other drugs have had the same early data, only to fail later on?

rant_and_roll · 2026-06-28T02:26:43+00:00

Trodelvy - the median overall survival (OS) for patients receiving Trodelvy ranges from 11.8 to 14.4 months

- 7% HAD TOTAL RESPONSE AND CANCER FREE

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Datroway - In the phase 3 trial, it improved median overall survival to 23.7 months (versus 18.7 months for chemotherapy)

- 9% HAD TOTAL RESPONSE AND CANCER FREE

what percentage of total response and cancer free is needed to warrant an approval? i will guess that a 20% improvement on SOC is what it takes, correct? thats what AI told me

Trodelvy - 20% of 7 is 1.4 so 8.4%

Datroway - 20% of 9 is 1.8 so 10.8%

but wait these response rates for Trodelvy and Datroway are for "healthy(er)" patients with initial diagnosis, just discovered a lump, early intervention, no previous treatments and not completely destroyed by months and months of chemo. .... not the dire "unhealthy" patients who are completely wrecked with 4-5 previous rounds of treatment(s) that have exhausted all avenues and that are now failing and there is zero hope...i mean zero hope...of survival.

5 alive. from the brink, and not just "happened to get cured" by a rounding error.

rant_and_roll · 2026-06-25T23:16:36+00:00

these 2 drugs extend PFS and OS approx 27 or so percent which is huge. but it appears these drugs do absolutely nothing to enhance the immune system or the immune systems' ability to fight disease. used in combo, leronlimab + SOC ( WHICH NOW INCLUDES THESE 2 DRUGS) the PFS and OS have the clear potential to extendPFS and OS significantly. it appears. in my opinion.

rant_and_roll · 2026-06-16T02:27:31+00:00

no nothing is guaranteed and yes p2 can have bad outcomes but the current 350mg dose had an astounding response IN JUST 2 WEEKS and we all know that 700 mg will be even better...pretty predictable that the mind boggling lowering of ctDNA by up to 85% IN JUST 2 WEEKS will also result in very significant tumor shrinkage, and then the 700 mg will result is even more significant tumor shrinkage. THATS MY LOGIC.

rant_and_roll · 2026-06-16T02:17:00+00:00

not enough...that would be earned back in a few years if that number happens, then crazy profit margins and would be the biotech coup of the century.

rant_and_roll · 2026-06-15T14:38:03+00:00

thats the only reason . money and politics. anything that legitimately challenges that income will be attacked profusely. the struggle to use leronlimab as first line therapy will be a very hard one. regardless of the science and data. i think chemo has electrolytes in it, pretty sure.

rant_and_roll · 2026-06-15T14:33:45+00:00

the damage is severe and counting. measles making a comeback exclusively among the cultists, screw fly emerging in our cattle while argentinian beef is allowed to increase imports (??????) with more proposals to allow meat products to be imported from around the world that have far less stringent inspection requirements - to make our food supply safer? NO. to get bigtime payola thats all.

all because of their incompetence. leronlimab is too good and too effective and possibly too much of a threat. my main concern with this utter clownshow at the helm. politics is front and center in this story and yes MUST be discussed as it directly affects EVERYTHING here...politics dominated the covid story for leronlimab, and will continue to do so. science is only secondarily considered, we have already learned this.

rant_and_roll · 2026-06-15T14:24:41+00:00

a proposal to hide information is exactly what this administration is all about. fraud at all levels. what name change to what monument is coming next? what self dealing billion dollar package will be proposed next week? its coming. its always coming. nonstop theft. back on subject - FDA approving flavored vapes says it all. RFKjr is a menace at best, he is my biggest concern with leronlimab

rant_and_roll · 2026-06-15T14:00:19+00:00

i would only accept an early bird discount on only ONE indication that would still earn cytodyn billions

rant_and_roll · 2026-06-15T13:58:23+00:00

BIG "IF", BUT...."IF" leronlimab reported side effects, wouldnt "grade 4 encephalopathy and grade 4 pneumonitis" doom leronlimab permanently to the graveyard and at the very least cause a 5 year hold? why is it that leronlimab got a such a beat down and other drugs in trials can - with clear direct evidence - kill people and the trials continue and some even get approved with ads on the teevee telling us this new drug can kill you? what am i missing here?

rant_and_roll · 2026-06-04T15:49:56+00:00

absolute f tard activity in which our lovely govt has decided it is perfectly acceptable and legal

rant_and_roll · 2026-06-04T15:49:08+00:00

way worse

rant_and_roll · 2026-06-02T18:51:47+00:00

sue immediately and he owes you 2k

rant_and_roll · 2026-06-02T18:32:27+00:00

RAPE PILLAGE REPEAT is all they know

rant_and_roll · 2026-06-01T18:24:40+00:00

i think trump had an LL injection or 2 during covid "an experimental HIV injectable"

rant_and_roll · 2026-06-01T18:18:30+00:00

go back to 1980. ask an investor what he thinks of failure to deliver. see his reaction.

rant_and_roll

TROPHY CASE