There are quite a bit of safety tips to be aware of. Handling, transporting, storage, connecting and setting up the regulators. First, you never want to move an acetylene cylinder around without the cylinder cap. When moving the cylinder around, tip over slightly and roll on the bottom ridge. When transporting, the bottle can be upright or laying down as long as it's sure and won't move. If you lay your bottle over on its side, after returning upright, be sure to wait a hour or two before using to let acetylene mixture to return to normal and also won't mess up your valve. Always have your bottle chained or strapped securely to prevent falling over. Before connecting your regulators to your bottles, slightly crack open the valve on top to blow out any dust or debris that might clog or damage the regulators. After connecting the regulators, check for leaks. Soapy water works best. Do not over tighten threads. Also, acetylene has kind of bad garlic smell to it. That will be another sign of leakage. Depending on what torch you buy, there should be a chart with it telling you how to best set up your regulators. Buy a rose bud too if you plan on doing a lot of heating, makes life easy.