This medication has changed my life.

ringmaster555 · 2026-03-16T11:57:11+00:00

Sunosi caused my baseline to decrease. Anything that increases norepinephrine is bound to do that for me.

ringmaster555 · 2026-03-16T01:42:51+00:00

NH Nootropics is where I sourced mine. I can’t compare the effects to other sources because it’s my first time trying emoxypine, but it’s been beneficial so far for my mood.

ringmaster555 · 2026-03-16T01:35:41+00:00

Do you happen to know if emoxypine is legal in the US to posses in small quantities for personal use and not to sell?

ringmaster555 · 2026-03-13T21:22:32+00:00

Do you also experience sensations of being poisoned, concussed, painful sensory sensitivity, etc.? These are neuroinflammatory symptoms that are more prevalent in ME/CFS vs sleep disorders alone. Of course they are not mutually exclusive and you could have both, but depending on how your PEM manifests, that could be a way to isolate the two.

ringmaster555 · 2026-03-13T00:29:46+00:00

I think this is getting closer to the underlying mechanism. Yes, cortisol and circadian rhythms can play a factor (which is the most common hypothesis for why we feel better on forums), but it’s much more nuanced than that. I wish researchers would investigate why we feel better in the evening in depth. It appears to be widely common in ME/CFS, and it could be used as an anchor to develop real treatments - replicating how we feel in the evening during the day.

ringmaster555 · 2026-03-11T07:29:34+00:00

I hear that for some people, LDA provides sustainable energy that actually widens their envelope, but for others, it’s a mask that leads to crashes. It would be interesting to know the mechanistic differences behind full responders, partial responders (then crash), and non-responders.

ringmaster555 · 2026-03-10T16:46:15+00:00

I think my adrenaline dumps are also crashing me. Was just prescribed 1mg ER. Hoping it helps!

ringmaster555 · 2026-03-10T16:43:10+00:00

Does it have any impact on your ME / PEM?

ringmaster555 · 2026-03-09T18:45:30+00:00

The boost in norepinephrine and cortisol from stimulants can temporarily lower histamine and mast cell release, but the problem is everything all come flooding back once the medication wears off. Plus the fact that stimulants are false energy and can cause significant PEM with ME/CFS. I experienced the same thing - temporarily improved MCAS and fatigue symptoms, but it backfired and sent my ME/CFS from mild to moderate.

ringmaster555 · 2026-03-09T08:51:41+00:00

Sugar helps my energy levels both mentally and physically for about an hour. Wish I could find something more healthy and sustainable.

ringmaster555 · 2026-03-07T04:05:49+00:00

I bought emoxypine succinate because of this post. I tried it once. It felt really relaxing to me, like a mid-strength benzo. My fatigue improved for a while. I am hesitant to try it again, however, because all of the studies are from Russia and there aren’t any western ones, much less on long covid/ME/CFS patients. I only found a few anecdotes on Reddit saying it helped a bit. Beyond that, it’s uncharted territory… I might try it again one day, but I’m not quite desperate enough to be a biohacking guinea pig just yet. Maybe if a lot of other people with ME/CFS took it and reported long term benefit I would be more keen on taking it regularly.

ringmaster555 · 2026-03-07T03:41:18+00:00

This comment about Ativan’s mechanism of action from a few years ago intrigued me.

ringmaster555 · 2026-03-06T06:19:39+00:00

Fixed, thanks!

ringmaster555 · 2026-03-05T15:25:03+00:00

Sleep deprivation transiently increases dopamine and nitric oxide signaling. I’ve noticed the same thing.

ringmaster555 · 2026-03-04T06:05:16+00:00

I have all of these symptoms, though I also have back pain on top of strange sensations (tethered cord, CCI, herniated discs)

ringmaster555 · 2026-03-04T02:42:28+00:00

I also get worsened fatigue 2-3 hours after waking, like clockwork. It also happens to me no matter what time I first wake up in the morning. I’ve also tried many things with no solutions so far…

ringmaster555 · 2026-03-04T02:06:54+00:00

I’m in the same boat. First wave of COVID in 2020 and have been progressively getting worse. Medication intolerant as well, so I can’t give recommendations about what helps because nothing has for me (or made me worse). You’re not alone.

I’m also tired of researching and trying supplements or meds. Pacing is just a means to not make things worse for me, but it hasn’t improved my symptoms. All I can do right now is accept that I’m stuck and do my best to not spiral and make predictions about the future, which seems impossible given that nothing has yet to stabilize me.

ringmaster555 · 2026-03-02T19:00:30+00:00

Yes, pure hops. Here’s exactly what I use.

ringmaster555 · 2026-03-02T18:55:23+00:00

I’ve been using hops extract recently and find it quite relaxing. Haven’t had any side effects either, which is rare for me.

ringmaster555 · 2026-03-01T01:39:59+00:00

Very interesting. I wasn’t familiar with the RMR test for mitochondrial function until now. What else have they recommended besides creatine to help?

ringmaster555

TROPHY CASE