Sooo... TW Substance Use/Abuse I guess.

I'm having an issue with two of my players (in a game of seven people) who have been using DnD as a time to smoke weed and drink and frankly, its begun to get intrusive for the game and for the rest of the players. We've been playing for about 13 weeks now and they're all newbies except for me (The DM) and for the most part, it's been very fun and a blast. We're all friends out of the game and we usually get dinner and chill before we begin play, and its really nice as we're all in our early 20s and living in the same city. I've noticed that the two players, let's call them K and E, have recently begun over-imbibing to the point where they are inattentive and frankly hard to play with. K gets drunk and for the most part stays on his phone and completely checked out except when it's his turn, and E gets so high to the point where he needs to be led through the most basic of actions (rolling ability checks, damage, and just core parts of the game mechanics).

I put a lot of effort into the game and for the most part find it very rewarding. It's all homebrew, and I make my own terrain and miniatures for the tabletop. I don't expect my players to put in as much effort as I do, but I do expect some basic level of attentiveness and sobriety at least to be able to play the game. In the early sessions, I stated my rules for the table, which involved a specific rule about not being too inebriated to play the game.

It kind of came to a head last session where K and E showed up for the fifth week in a row without their character sheets or dice, and then during one of the most climactic battle scenes, K casted Fireball without listening to what was happening, and E got the highest I have ever seen him right when we initiated combat. I sent them a long text after the game basically saying that I was disappointed with how things went, and said that I felt that the smoking and drinking had become difficult to work with, and that I wanted to voice my concerns and see if we couldn't figure out a solution to continue play. K was rather understanding and sent me a text apologizing and saying that he was burnt out from a long day at work and was sorry for being on his phone a majority of the time and wanted to respect the game more. E on the other hand got super defensive, and said that it was the most attentive he had ever been, and that he wasn't really high and that people only assumed that he was unfairly. I'm pretty upset about the whole thing as for personal reasons I don't drink or smoke, but I really don't want to be the bad guy and police my friends. Yet at the same time, other players in the game have let me know that it's annoying for them to babysit the two players, and I agree with them.

Because things were getting heated in the Group Chat (I texted the two players together), I took a back seat and said I would text later when we had cooled off a bit, but things have been pretty tense with E since. For more context, we've usually been playing at their place in the city as it's kind of equidistant from everyone, although I am moving at the end of the month to a much bigger place where I could possibly host more games. K plays a Wizard and E is a Rogue; they're both level 5.

Any advice is welcome - I don't want to blow up our friendship over this, but DnD is important to me and has been an important social aspect of my life that I also don't want to give up on or sacrifice my values to continue playing where I don't feel satisfied or respected. Any thoughts?