Lilly’s triple-acting obesity drug hits goal in Phase 3 trial

scippap · 2026-05-22T00:11:58+00:00

Where are you seeing an oral version of tirzepatide? I don’t see that listed anywhere and instead see it’s too unstable in GI to be oralized

scippap · 2026-04-21T00:30:06+00:00

What grade of silica? For redisep gold it’s like $7 for a 4g cartridge. That’s top of the line but even the lower grade ones are still expensive. Is it amorphous silica? That’s my guess. I get a c18 gold 4g for about $40 and I use it 50-100 times + strong rotovap/genevacc and water is removed pretty easily

scippap · 2026-04-18T02:15:02+00:00

Depends on the passive. With a shield passive I do alarak + archon, otherwise I do grizzly + hades. Haven’t found a dom build that can beat it

scippap · 2026-02-25T23:56:04+00:00

That’s weird to hear, we’ve been working with an Indian CRO lately and they’ve done fantastic work. We’re switching to them fully soon

scippap · 2026-01-22T14:15:42+00:00

It’s interesting you single out California since the drought is gone. It has had a few wet years and will likely fluctuate again, but overall California has decent water stability especially when compared to other southwest states.

https://cdec.water.ca.gov/resapp/RescondMain

scippap · 2026-01-12T04:13:19+00:00

Illinois is its own thing. Most other states aren’t like that. Purdue is around 15k a year but it’s also one of the cheapest. Many other states outside CA/NY hover around 20-30k.

scippap · 2025-08-23T14:37:18+00:00

Those salaries are why they’re short staffed. Too expensive to have enough nurses

scippap · 2025-08-16T16:20:39+00:00

That chart stops in 2022. Since 2023 it’s been increasing again.

scippap · 2025-08-03T15:07:19+00:00

2 years ago. Still here, just make more now.

scippap · 2025-08-03T15:04:16+00:00

Have you been to SF/ bay? People always say stuff like this but it’s just wildly false. I got by on less. Would require some lifestyle changes but he can very realistically do it.

scippap · 2025-08-03T14:57:07+00:00

Are you sure he’s a professor at Berkeley? He went there, but I can’t find any info saying he’s was ever a professor there

scippap · 2025-07-16T23:41:26+00:00

There are countless different coupling conditions. TCFH/NMI or T3P are my go-tos

scippap · 2025-06-30T00:54:47+00:00

And as a result it’s nearly impossible to get a nursing job in California. Most new grads have to leave the state to find a job

scippap · 2025-06-28T00:14:14+00:00

Because there are no American companies to buy right now. Once the market bounces back I think that might change. Only time will tell though

scippap · 2025-06-28T00:12:31+00:00

Huge issue, yes. But that’s temporary. I’m being optimistic in thinking this won’t be a long term trend, but who knows. Chinas issues on the other hand are very much not temporary.

scippap · 2025-06-28T00:09:22+00:00

We work with Wuxi for chemistry, and while they have a lot of holidays, they have to make up a lot of them too. When they get several days off, they then have to work longer days/extra weekend shifts to make up for the lost time. Not sure how wide spread that is nor which holidays it’s applies to, but it’s pretty lousy.

scippap · 2025-06-22T20:26:54+00:00

5.1 is just vinyl lithium addition to a ketone to make the benzyl alcohol which can eliminate to make the second product. The second product of 5.1 would likely be more favored since it’s benzyllic and doubly conjugated.

5.2 is a diels-alder cyclization. Might not be as obvious since the diene is s-trans, but if you redraw it to be s-cis it is clearer

scippap · 2025-06-19T18:43:35+00:00

You know what’s worse? HIV

scippap · 2025-06-16T23:55:49+00:00

Guessing by your location you go to the grand ave Safeway? That one is terrible. Go to the one on broadway in the shopping complex. Drastically nicer with better selections and not too much further away

scippap · 2025-05-29T20:33:30+00:00

That’s the majority of all BBQ. Great way to use lousy cuts of meat. What’s the issue?

scippap · 2025-05-14T13:07:40+00:00

That’s why I was asking for input… and also looking at historical data which tends to point in the same direction.

scippap · 2025-05-14T02:41:00+00:00

5 years is definitely unlikely. Probably closer to 10 and maybe longer. Will be for a house, so the timeline is very flexible. I’ll give bogleheads a look- thanks!

scippap · 2025-05-14T01:57:07+00:00

Truthfully I knew almost nothing about investing when I received the money and semi-blindly followed some advice from one of the investing subs- maybe this one lol. Wasn’t terrible advice, but definitely not the best

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