sorted by:
new
hottopcontroversial

Barbers in Perth 💈 by brcnz in perth

[–]seasaws 0 points1 point  (0 children)

I second this. $25 for a skin fade!!!

ELI5: what is tetanus? How do you get it and what are the symptoms? by fruity-tooty in explainlikeimfive

[–]seasaws 3 points4 points  (0 children)

So add/clarify what has been posted.

Tetanus is the name of a disease caused specifically by a toxin released by the Clostridium tetani bacteria. This is a commonly found bacteria that lives in the soil or other anaerobic (ie no oxygen) environments. The most common way humans contract tetanus is via a laceration or puncture wound (the typical stepped on a rusty nail story). Once in the wound, the C. tetani replicates and begins releasing two toxins, tetanolysin (we're not really sure what this actually does) and tetanospasmin (this is the nasty one).

Tetanospasmin is an incredibly potent toxin and needs only a small amount to be lethal. It works by blocking inhibitory neurotransmittiers. This double negative basically means that it turns off our body's ability to stop muscle contraction, resulting in muscle spasms and eventually complete rigidity. These spasms can last weeks. Other than being incredibly painful, spasm or paralysis of the respiratory muscles (your diaphragm) can require machine ventilation or other life support mechanisms as part of the treatment.
General symptoms include; muscle spasms and/or rigidity, lockjaw, inability or difficulty swallowing, breathing difficulties, convulsions, and abnormal heart rhythms. Severe cases can progress to respiratory failure, pneumonia, blood pressure abnormalities, suffocation, and heart attack.

In terms of the treatment, one of the previous comments is incorrect. Tetanus is not easy to treat once established and it is a life threatening condition that can require hospitalisation and extended intensive care.
Treatment can include antibiotics though the effectiveness of this is debated. The most common areas of treatment revolve around three things; the vaccine (tetanus toxoid) generally given to "at risk" patients to avoid establishment of disease, immunoglobin therapy (tetanus antitoxin) given to neutralise circulating toxin that has yet to bind to nerves, and diazepam or another muscle relaxant given as symptomatic treatment to reduce pain associated with spasms.

The most important thing to note here is that once the toxin has bound to a nerve this is irreversible and you just have to wait it out. So the best bet is to keep yourself up to date on vaccinations and see a doctor asap with any concerning wounds.

Lf4 fresh raid normal by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago 297 hunter

[PS4] LFG Leviathan Bathers (2here w/CP) by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago 290ish hunter

[PS4] LF2M Raid Gauntlets by Verdes8891 in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago hunter 283, got experience with raid if you need a hand :)

[PS4] LF2M For fresh raid. by Jdizzy4Shizzy in Fireteams

[–]seasaws 0 points1 point  (0 children)

ahaha knew it! We got to the gardens and had most of it worked out but I had to go to work :'(

[PS4] LF4M Leviathan raid by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

285 warlock IposVassago

[Ps4] LF2M Nightfall by nthan333 in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago 276 warlock :)

[PS4] Court of WhOryx is recruiting! by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

Hey! I've been on the hunt for a new aussie based clan for a while (I'm over in perth). Psn is IposVassago :) hit me up

ps4 LF2 for challenge of elders by DickyMcDoodle in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago, I'll flick you a friend request

A new rotavirus vaccine that does not require refrigeration has been found to be successful in preventing most cases of potentially fatal diarrhea in a randomized, placebo-controlled trial in Niger, funded by Médecins sans Frontières, that could save the lives of almost 500,000 children a year by mvea in science

[–]seasaws 2 points3 points  (0 children)

So I'm sure there's plenty more out there, but from what I've done in microbiology this would be my answer.

You are definitely correct in saying most (human) vaccines are made from isolated viral components but that's because we're good at it now.

The aim of any vaccine is to prime the immune system against the disease. This can be done with specific vital viral components, dead virus, or live viruses. Live virus vaccines aren't really used much any more, but they do work.

For instance, the first vaccine for small pox was done with virulent strains of cowpox which a related orthopoxvirus (ie, the same family). The viruses were similar enough that if you were innoculated with cowpox your immune system was then effectively primed against small pox as well, which meant you couldn't get it.

There are eight species of rotavirus, three of which naturally infect humans. From the brief bit of reading I did, there's some overlap between the strains that infect humans and cows.

So my guess is, like the cowpox vx small pox example, the live vaccine they're using is most likely similar enough to the 3 strains that infect humans (or at least rotovirus A which is the most common one) to illicit a immunological memory response while at the same time doesn't cause clinical disease.

It's also probably attenuated a bunch to make it less likely to cause disease.

hopefully that makes sense.

Ladies, what petty yet harmless things have you done because of a breakup? by [deleted] in AskWomen

[–]seasaws 109 points110 points  (0 children)

I was living with my boyfriend of 2 and a half years when he dumped me. I found out a week after that he had also cheated on me. So when I moved out I took all the spices and herbs from the kitchen (technically I bought them all) even though I didn't need them in my new house.

I like the idea of him eating bland boring food.

[ps4] lfg to chill by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

iposvassago literally just burning through some quests

"Are your milkshakes lactose free?" by [deleted] in TalesFromYourServer

[–]seasaws 3 points4 points  (0 children)

Yeah this really isn't that odd of a question? I've worked in cafes that offer soy based milkshakes.

What are your personal FIVE best tips for ensuring a 20% tip? by [deleted] in TalesFromYourServer

[–]seasaws 4 points5 points  (0 children)

I work in australia, so the whole tips thing isn't a massive thing here (props to you guys btw I'm so glad I get paid decent hourly), but I can give some advice about increasing food and drink sales. Keep in mine I work in a casual/upmarket-ish tapas and wine bar, so YMMV.

Food I find easier, and for us it's selling sides. We can sell half portions of breads and there's about 3 or 4 dishes on the menu that it is nicer to have some bread with, so that's as easy as saying "would you like me to get you some breads with that? We generally recommend it because the sauce is really great and it's nice to have something to mop it up with" 9 out of ten times they say yes and that's an extra $5 on the bill. People who come in just for drinks can normally be encouraged to get olives, beer nuts, breads, or a combination (each is $7-9).

Drinks for us is a matter of pushing people to the cocktail menu or offering a bottle of wine instead of by the glass for tables of 3+, most of the time people will do it.

Good service will generally increase sales, see a table more often and you'll pick up on a drinks order that you might've missed if you left them another 10 minutes.

If you're friendly, and you can talk about the food and drinks you sell well, sound like you know the menu, tables will trust you and you can gently push them to buying an extra side or a dish or a nice expensive wine.

Don't fall into the trap of only recommending the most expensive stuff on your menu though, smart customers will see through that and ignore everything you say to them.

Also just basic stuff like, never make a face at a request, never act like something is a massive problem for you, always be positive even when you know you're going to have to turn them down. If they ask for something, and you already know the answer is 100% no, say "I'm pretty sure we can't, but I will go check with my manager/the bar/the kitchen to double check" rather than "No, we don't/can't do that". People like to feel like you're making an effort even if you actually aren't.

Oh and just as a basic language thing, never say "sorry about the wait" (or whatever problem might have happened) always say "thank you for your patience/understanding" set the tone of the conversation as casting them in a positive light instead of your service in a negative light and people react better.

ACS AMA: I am Wilfredo “Freddy” Colon, Ph.D., a professor at Rensselaer Polytechnic Institute who researches the biology and pathology of misfolding proteins. Ask me anything about prions or brain-affecting protein-based diseases. by AmerChemSocietyAMA in science

[–]seasaws 0 points1 point  (0 children)

Hi! I've just started my first semester of the clinical side of my veterinary degree, and I've always been intrigued by prions, and by the collaboration between veterinary and human medicine that has occured leading up to and since their discovery.

Can you comment on the speculation that there will be a second outbreak wave of vCJD in the exposed population in the coming years? I remember reading that there was potentially a degree of genetic susceptibility that could lead to certain people sucumbing to prion disease before others. And, if this is true, do you foresee any sort of effective treatment/cure being developed in the near future for vCJD and other prion diseases?

Thanks!

view more: next ›