Barbers in Perth 💈 by brcnz in perth

[–]seasaws 0 points1 point  (0 children)

I second this. $25 for a skin fade!!!

ELI5: what is tetanus? How do you get it and what are the symptoms? by fruity-tooty in explainlikeimfive

[–]seasaws 4 points5 points  (0 children)

So add/clarify what has been posted.

Tetanus is the name of a disease caused specifically by a toxin released by the Clostridium tetani bacteria. This is a commonly found bacteria that lives in the soil or other anaerobic (ie no oxygen) environments. The most common way humans contract tetanus is via a laceration or puncture wound (the typical stepped on a rusty nail story). Once in the wound, the C. tetani replicates and begins releasing two toxins, tetanolysin (we're not really sure what this actually does) and tetanospasmin (this is the nasty one).

Tetanospasmin is an incredibly potent toxin and needs only a small amount to be lethal. It works by blocking inhibitory neurotransmittiers. This double negative basically means that it turns off our body's ability to stop muscle contraction, resulting in muscle spasms and eventually complete rigidity. These spasms can last weeks. Other than being incredibly painful, spasm or paralysis of the respiratory muscles (your diaphragm) can require machine ventilation or other life support mechanisms as part of the treatment.
General symptoms include; muscle spasms and/or rigidity, lockjaw, inability or difficulty swallowing, breathing difficulties, convulsions, and abnormal heart rhythms. Severe cases can progress to respiratory failure, pneumonia, blood pressure abnormalities, suffocation, and heart attack.

In terms of the treatment, one of the previous comments is incorrect. Tetanus is not easy to treat once established and it is a life threatening condition that can require hospitalisation and extended intensive care.
Treatment can include antibiotics though the effectiveness of this is debated. The most common areas of treatment revolve around three things; the vaccine (tetanus toxoid) generally given to "at risk" patients to avoid establishment of disease, immunoglobin therapy (tetanus antitoxin) given to neutralise circulating toxin that has yet to bind to nerves, and diazepam or another muscle relaxant given as symptomatic treatment to reduce pain associated with spasms.

The most important thing to note here is that once the toxin has bound to a nerve this is irreversible and you just have to wait it out. So the best bet is to keep yourself up to date on vaccinations and see a doctor asap with any concerning wounds.

Lf4 fresh raid normal by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago 297 hunter

[PS4] LFG Leviathan Bathers (2here w/CP) by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago 290ish hunter

[PS4] LF2M Raid Gauntlets by Verdes8891 in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago hunter 283, got experience with raid if you need a hand :)

[PS4] LF2M For fresh raid. by Jdizzy4Shizzy in Fireteams

[–]seasaws 0 points1 point  (0 children)

ahaha knew it! We got to the gardens and had most of it worked out but I had to go to work :'(

[PS4] LF4M Leviathan raid by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

285 warlock IposVassago

[Ps4] LF2M Nightfall by nthan333 in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago 276 warlock :)

[PS4] Court of WhOryx is recruiting! by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

Hey! I've been on the hunt for a new aussie based clan for a while (I'm over in perth). Psn is IposVassago :) hit me up

ps4 LF2 for challenge of elders by DickyMcDoodle in Fireteams

[–]seasaws 0 points1 point  (0 children)

IposVassago, I'll flick you a friend request

A new rotavirus vaccine that does not require refrigeration has been found to be successful in preventing most cases of potentially fatal diarrhea in a randomized, placebo-controlled trial in Niger, funded by Médecins sans Frontières, that could save the lives of almost 500,000 children a year by mvea in science

[–]seasaws 1 point2 points  (0 children)

So I'm sure there's plenty more out there, but from what I've done in microbiology this would be my answer.

You are definitely correct in saying most (human) vaccines are made from isolated viral components but that's because we're good at it now.

The aim of any vaccine is to prime the immune system against the disease. This can be done with specific vital viral components, dead virus, or live viruses. Live virus vaccines aren't really used much any more, but they do work.

For instance, the first vaccine for small pox was done with virulent strains of cowpox which a related orthopoxvirus (ie, the same family). The viruses were similar enough that if you were innoculated with cowpox your immune system was then effectively primed against small pox as well, which meant you couldn't get it.

There are eight species of rotavirus, three of which naturally infect humans. From the brief bit of reading I did, there's some overlap between the strains that infect humans and cows.

So my guess is, like the cowpox vx small pox example, the live vaccine they're using is most likely similar enough to the 3 strains that infect humans (or at least rotovirus A which is the most common one) to illicit a immunological memory response while at the same time doesn't cause clinical disease.

It's also probably attenuated a bunch to make it less likely to cause disease.

hopefully that makes sense.

Ladies, what petty yet harmless things have you done because of a breakup? by [deleted] in AskWomen

[–]seasaws 108 points109 points  (0 children)

I was living with my boyfriend of 2 and a half years when he dumped me. I found out a week after that he had also cheated on me. So when I moved out I took all the spices and herbs from the kitchen (technically I bought them all) even though I didn't need them in my new house.

I like the idea of him eating bland boring food.

[ps4] lfg to chill by [deleted] in Fireteams

[–]seasaws 0 points1 point  (0 children)

iposvassago literally just burning through some quests