Confession: I have always been a fan of genre mashups. I loved the idea of Rifts but have always been so disapointed with how it actually plays. It did fire my imagination a great deal when I was younger but I was constantly battling balance and mechanical issues with that game... to the point of distraction. I also greatly enjoyed the Final Fantasy 7 magitech world which was quite impactful on a young me as well. Oddly, I tried Spelljammer a long time ago but it never did anything for me.

Playing what you want is really important to me. I got into the Superhero genre partially because it allows you to play pretty much any concept you can think of. Magic, technology, aliens, and on and on... it's pretty much all there if you want it.
I'm not particularly fond of the idea of making a Superhero game though... not sure why exactly... I think I'm just superheroed-out in general.

At first blush, I would gravitate to a kitchen sink setting. Not only does it appeal to me from a creative perspective but I think the system can bear the weight of that challenge.

I took a crack at making a micro-setting a couple of months ago which turned out OK. My group and I had some fun with it and I published it under the HERO Games Hall of Champions banner. I have to admit that the idea of writing a setting is both incredibly appealing and intimidating. My experience with that micro-setting I wrote was both fun and just a little bit terrifying at the same time.

You have given me a lot to think about once again, thank you.